A series of four images shows individuals with PPE in a lab setting, and one individual on a laptop

JGI researchers demonstrate how their laboratory and data science efforts support users, advance foundational science and enable biotechnology discoveries. (Pictured from left to right: Peng Wang, Sravanthi Tejomurthula, Mi Yan, Deanna Beatty) 

 

Vision 

Lead AI-driven genomic innovation to advance biotechnology.

Mission 

As a U.S. Department of Energy Office of Science user facility supported by the Biological and Environmental Research program, the Joint Genome Institute provides advanced genomic capabilities, large-scale AI-ready data and professional expertise to support the global research community in studies of complex biological and environmental systems. We optimize our service to the community through responsibly managing our people and resources.

 

Director's Perspective

 

 

 

Honors & Awards

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    Nigel Mouncey, Director, named AAAS Fellow for contributions to genomics and integrative genome science capabilities
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    Simon Roux, Viral Genomics Group Lead, receives ASM Microbiome Data Prize for advancing microbial sciences through innovative microbiome data analysis
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    Jonelle Basso, Plant Microbial Interactions Group, receives Berkeley Lab Director's Award for Mentorship for advocacy, professional development, and fostering scientific collaboration
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    Kjiersten Fagnan, Chief Informatics Officer, receives Berkeley Lab Director's Award for Organizational Impact for advancing computational infrastructure and data-sharing in biological research
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    Heejung Cho, Plant-Microbial Interactions Group, finalist in 2025 Berkeley Lab Research SLAM with talk on phages
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    Nine JGI researchers named Clarivate Highly Cited Researchers 2025 for ranking in top 1% by citations: Emiley Eloe-Fadrosh, Marcel Huntemann, Igor Grigoriev, Natalia Ivanova, Nikos Kyrpides, Simon Roux, Jeremy Schmutz, Axel Visel, and Tanja Woyke

 

Accomplishments at a Glance

Below are briefs on some of the scientific collaborations that came out of the JGI in 2025, as well as highlights around our outreach efforts.
Science Feature
GenomeOcean Leverages AI to Decode Nature’s Secret Language
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DOE Science Highlights
A Cost-Efficient Way to Convert Yeast into a Cell Factory for Hydroxyapatite
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Science Feature
DAP-seq Drives Robust Mapping of Gene Regulation
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DOE Science Highlights
Cataloging the Microbes that Manage the Health of River Systems
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Science Feature
Mapping the Earth’s Hidden Fungal Kingdom
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Science Feature
Taking Stock of the Known and Unknown Microbial Space
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DOE Science Highlights
A Community Resource for Secondary Metabolite Researchers
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DOE Science Highlights
A Revamped Amplification Method that Enables Nearly Complete Single-Cell Genomes
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DOE Science Highlights
Marchantia Pangenome Highlights Adaptive Nature of Plant Lineages
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DOE Science Highlights
New and Improved: Eucalyptus Reference is Now Accessible
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DOE Science Highlights
Team Science Reveals Important Protein in Poplar
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DOE Science Highlights
Data Discovery Tool Helps Identify Microbial Roles within Metagenomes
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DOE Science Highlights
Identifying the Microbial Cleanup Crew at a Superfund Site
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DOE Science Highlights
Open Frameworks Training the Next Generation of Scientists
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Outreach
Expanding Horizons with the 2025 JGI-UC Merced Internship Cohort
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Outreach
Building Wet and Dry Lab Skills
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Outreach
Charting Progress toward Professional Goals
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Impact: By the Numbers

Spending Profile
This image is a donut chart depicting the FY2025 spending profile: Science Programs & Analysis 34.8%, Genomic Technologies 32.2%, Data Science & Informatics 15.6%, Management 8.0%, Project Management Office 4.3%, Compute Infrastructure & Support Team (@NERSC) 3.0%, and Operations 2.0%.
 Users on the Global Map 
This image is a world map showing the geographic distribution of 2,627 primary users. North America has 1,774 users (1,672 in the U.S.), followed by Europe with 589. Other regions include Asia (113), Australia/New Zealand (77), South America (54), and Africa (18). A sector breakdown shows 1,934 academic users, 24 from industry, 210 from DOE national labs, 277 from government, and 162 from other sectors.
RegionCountRegionCountRegionCount
North America1,774Asia113Europe589
United States1,672China28Austria19
Canada92India13Belgium24
Mexico9Israel18Croatia1
Panama1Japan31Czech Republic18
  Malaysia1Denmark21
Australia + New Zealand77Saudi Arabia3Finland22
Australia60Singapore5France78
New Zealand17South Korea11Germany99
  United Arab Emirates2Greece12
Africa18Viet Nam1Hungary13
South Africa16  Ireland1
Tunisia1South America54Italy30
Namibia1Argentina1Netherlands40
  Brazil42Norway 21
  Chile3Poland3
  Colombia3Portugal8
  Ecuador1Russian Federation5
  Peru3Slovenia3
  Paraguay 1Spain34
    Sweden28
    Switzerland14
    Turkey1
    Ukraine1
    United Kingdom93
      
 
Users on the U.S. Map
This image is a U.S. map displaying the distribution of 1,672 primary users by state. States are color‑coded by user count: dark orange marks the highest values (up to 365 users), medium orange indicates 30–86 users, green represents 11–29 users, and blue shows 0–10 users. A sector breakdown lists 1,266 academic users, 210 from DOE national labs, 82 from government, 20 from industry, and 94 from other sectors.
 
Cumulative Number of Projects Completed & Cumulative Number of Scientific Publications
 
This image presents two cumulative growth charts from 2016 to 2025: the left blue chart shows projects increasing from 23,047 in 2016 to 349,105 in 2025, with sharp gains after 2019; the right green chart shows scientific publications growing from 1,555 to 3,574 over the same period, with steady year-over-year increases.
 Sequencing Output 
(in trillions of bases or Tb)

The JGI supports short- and long-read sequencers, where a read refers to a sequence of DNA bases. Short-read sequencers produce billions of paired-end 150 basepair reads used for genomic minimal draft assembly and resequencing projects, as well as for RNAseq annotation and quantification, such as in gene expression analysis. Long-read sequencers currently average 60,000–70,000 bp reads and are used for high-quality de novo genome assembly and full-length RNAseq transcript sequencing. Combined short-read and long-read totals per year give JGI’s annual sequence output. The total sequence output in 2025 was 1,144.186 Tb.

FY 2016–FY 2025 sequencing throughput: Single Molecule Long-Read Sequencing rises from 1.9 to 578.8, while Massively Parallel Short-Read Sequencing ranges from 140.0 to 565.4, peaking in 2024 at 568.3. Long-read volumes accelerate sharply after 2019, nearly matching short-read totals by 2025.
 Users Letters of Intent/Proposals Submitted & Approved

Bar charts comparing FY 2024 vs. FY 2025 letters of intent (submitted and approved) and proposals (submitted and approved) for the Community Science Program (CSP), FICUS (JGI-EMSL), New Investigator, and Functional Genomics calls. Dark green/light green bars represent LOIs submitted/approved, and dark blue/light blue bars represent proposals submitted/approved. A note indicates that CSP and FICUS require letters of intent before proposal submission.

Computational Infrastructure: Users of JGI Tools & Data

Two individuals look at a laptop in hand while the other points to the screen. A lab setting is visible in the backdrop.
  • JGI Archive and Metadata Organizer (JAMO): 22.438 million file records
  • JAMO Archived Data Footprint: 20.288 Petabytes (PB)
  • Data Downloads in FY24
    • Genome Portal: 6.984 million file-downloads
    • Data Portal: 0.517 million file-downloads
    • Total: 7.501 million file-downloads
  • Data Downloads in FY25
    • Genome Portal: 3.534 million file-downloads
    • Data Portal: 3.662 million file-downloads
    • Total: 7.196 million file-downloads

The Genome Portal provides unified access to all JGI genomic databases and analytical tools. Users can search, download and explore data sets available for all JGI sequencing projects including their status, assemblies, and annotations of sequenced genomes. The Data Portal allows JGI users to more easily access public data sets through a common set of metadata across files submitted by each scientific program. The Genome Portal will be retired once the Data Portal reaches data- and feature-parity with its predecessor. Work remaining to be done includes: limiting payload size for two back-end endpoints, aggregating by IMG taxon OID when ITS IDs are not available, making all data visible to JGI employees, implementing redirects from GP to JDP, and converting User IDs to Contact IDs.  We are targeting a January 2026 shutdown. 

The JGI manages a bioinformatics cluster, Dori, situated at LBL's LabIT, and highly available web services infrastructure at IGB. The JGI's data management system, JAMO (JGI Archive and Metadata Organizer),  operates across data centers — both ingesting new data and delivering data stored at NERSC for processes running at these other centers. The JGI is working on a distributed version of JAMO that can be used by collaborators to manage data from instruments and analyses. JAMO will play a crucial role in ensuring high quality data and files are available through the new BRIDGE: Biological and enviRonmental Infrastructure for Data manaGement and Exploration initiative. 

As part of our business continuity planning, JGI has worked with the Environmental Molecular Sciences Laboratory to enable JAMO to automatically transmit and store files on EMSL's HPSS tape system via Globus. Currently, all new raw sequencing data is being transmitted. Over the next year, all legacy data will be restored from NERSC's tape system and transmitted automatically to EMSL.

 

Photography by Robinson Kuntz/Berkeley Lab. Director’s perspective footage, graphics and photos by: Menaka Wilhelm; Meghan Zodrow/Berkeley Lab; Graham Rutherford; Massie Ballon; OpenAI; Leo Baumgart, Sharon Greenblum and Ronan O’Malley; Bezhad Rad; Wu D, Seshadri R et al. Sci Adv. 2025, CC BY; Allison Joy; Jonelle Basso; Thor Swift/Berkeley Lab; Utumporn Yawichai; Tasha Kostyuk.

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