DOE Joint Genome Institute

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Streamlining Regulon Identification in Bacteria

Data yielded from RIViT-seq increased the number of sigma factor-gene pairs confirmed in Streptomyces coelicolor from 209 to 399. Here, grey arrows denote previously known regulation and red arrows are regulation identified by RIViT-seq; orange nodes mark sigma factors while gray nodes mark other genes. (Otani, H., Mouncey, N.J. Nat Commun 13, 3502 (2022). https://doi.org/10.1038/s41467-022-31191-w)

RIViT-seq technology could speed up associating transcription factors with their target genes. The Science                        Regulons are a group of genes that can be turned on or off by the same regulatory protein. Researchers demonstrated the efficacy and potential of regulon … [Read More]

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