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… metabolism. Hey everybody, this is Dan with episode 13 of National Prodcast. This continues our little section … a bit embarrassed that we recorded this conversation about 10 months ago. I was pretty green at the time and had some … to my daughters– what did they think would be important in 100 years. Would natural products be important for …

… getting them out to you all. But for now, here is episode 10 of Natural Prodcast, the primer on genome mining. Hey, … Microbiomes. Nature  Biotechnology . 2020 Nov 9. doi: 10.1038/s41587-020-0718-6) DAN UDWARY: Yeah, I think that might … Microbiomes” paper is here . Read the associated JGI news release here . Software we discussed, used for genome …

… like a nice summer day in Seattle I think this was like 2013 or 2014. And antiSMASH — I know you’ve interviewed Marnix … acyl-homoserine lactone signal . mBio. 2023 Aug 31;14(4):e0101023. doi: 10.1128/mbio.01010-23. Publication: Cummings …

… And you have these different types of particulate like 2.5, 10 PPMs and just the size of the particle and how far they … there a way to do that? DAN UDWARY: Well, so there’s good news and bad news on that. So one of the things that we’re trying to do …

… pairs. It was not linear, like Streptomyces , but circular. 10% of the genome encoded natural product pathways. Dan: … has been a lot of fun for us in recent years. Started in 2015, when two things happened. One, a new graduate student … still with us? Brad:  Unfortunately, not. We lost him about 13 years ago. So, I wish he was still with us because I know …

… So they’re in the picomolar range. ALISON: Picomole… is [10 to the] minus twelve, right? BEN: Yeah, yeah. Well, we … company Wyeth that introduced enediynes to the market in 2001 with a drug called Mylotag. Wyeth was later acquired by … So I wanted to ask you also about – because you were in the news recently – TSRI has acquired the Pfizer strain …

… never forced it on me, but we always had these scientific news magazines lying around at home. And I would just pick … had a high throughput screening platform where we’d look at 10,000, 15,000, 20,000 mutants a week. We started doing a … NIGEL MOUNCEY: Yeah, so we put out a strategic plan in 2018. And in building that plan, we thought about secondary …

… Resour Announc 0:e00891-25. https://doi.org/10.1128/mra.00891-25 . B. Christenson, I. Nouioui, C. Daum, … Microbiol Resour Announc 0:e00506-25. https://doi.org/10.1128/mra.00506-25 J. Cusack, I. Del Rio, S. Spring, N. … blood in Cleveland, Ohio. Microbiol Resour Announc. 0:e01296-24. https://doi.org/10.1128/mra.01296-24 V. Torres, R. …

… IP & Science arm of Thomson Reuters, has released their 2019 list of Highly Cited Researchers , which includes 10 affiliated with the JGI . The 2019 list focused on Highly … team established community gardens of switchgrass plants in 10 different field sites on a north-south gradient across …