Large-Scale Analyses of Human Microbiomes Reveal Thousands of Small, Novel Genes
Small proteins are traditionally overlooked due to computational and experimental difficulties in detecting them. To systematically identify small proteins, we carried out a comparative genomics study on 1,773 human-associated metagenomes from four different body sites. We describe >4,000 conserved protein families, the majority of which are novel; approximately 30% of these protein families are predicted… [Read More]