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    Data yielded from RIViT-seq increased the number of sigma factor-gene pairs confirmed in Streptomyces coelicolor from 209 to 399. Here, grey arrows denote previously known regulation and red arrows are regulation identified by RIViT-seq; orange nodes mark sigma factors while gray nodes mark other genes. (Otani, H., Mouncey, N.J. Nat Commun 13, 3502 (2022). https://doi.org/10.1038/s41467-022-31191-w)
    Streamlining Regulon Identification in Bacteria
    Regulons are a group of genes that can be turned on or off by the same regulatory protein. RIViT-seq technology could speed up associating transcription factors with their target genes.

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    (PXFuel)
    Designer DNA: JGI Helps Users Blaze New Biosynthetic Pathways
    In a special issue of the journal Synthetic Biology, JGI scientific users share how they’ve worked with the JGI DNA Synthesis Science Program and what they’ve discovered through their collaborations.

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    A genetic element that generates targeted mutations, called diversity-generating retroelements (DGRs), are found in viruses, as well as bacteria and archaea. Most DGRs found in viruses appear to be in their tail fibers. These tail fibers – signified in the cartoon by the blue virus’ downward pointing ‘arms’— allow the virus to attach to one cell type (red), but not the other (purple). DGRs mutate these ‘arms,’ giving the virus opportunities to switch to different prey, like the purple cell. (Courtesy of Blair Paul)
    A Natural Mechanism Can Turbocharge Viral Evolution
    A team has discovered that diversity generating retroelements (DGRs) are not only widespread, but also surprisingly active. In viruses, DGRs appear to generate diversity quickly, allowing these viruses to target new microbial prey.

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    Photograph of a stream of diatoms beneath Arctic sea ice.
    Polar Phytoplankton Need Zinc to Cope with the Cold
    As part of a long-term collaboration with the JGI Algal Program, researchers studying function and activity of phytoplankton genes in polar waters have found that these algae rely on dissolved zinc to photosynthesize.

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    This data image shows the monthly average sea surface temperature for May 2015. Between 2013 and 2016, a large mass of unusually warm ocean water--nicknamed the blob--dominated the North Pacific, indicated here by red, pink, and yellow colors signifying temperatures as much as three degrees Celsius (five degrees Fahrenheit) higher than average. Data are from the NASA Multi-scale Ultra-high Resolution Sea Surface Temperature (MUR SST) Analysis product. (Courtesy NASA Physical Oceanography Distributed Active Archive Center)
    When “The Blob” Made It Hotter Under the Water
    Researchers tracked the impact of a large-scale heatwave event in the ocean known as “The Blob” as part of an approved proposal through the Community Science Program.

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    A plantation of poplar trees. (David Gilbert)
    Genome Insider podcast: THE Bioenergy Tree
    The US Department of Energy’s favorite tree is poplar. In this episode, hear from ORNL scientists who have uncovered remarkable genetic secrets that bring us closer to making poplar an economical and sustainable source of energy and materials.

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    HPCwire Editor's Choice Award (logo crop) for Best Use of HPC in the Life Sciences
    JGI Part of Berkeley Lab Team Awarded Best Use of HPC in Life Sciences
    The HPCwire Editors Choice Award for Best Use of HPC in Life Sciences went to the Berkeley Lab team comprised of JGI and ExaBiome Project team, supported by the DOE Exascale Computing Project for MetaHipMer, an end-to-end genome assembler that supports “an unprecedented assembly of environmental microbiomes.”

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    With a common set of "baseline metadata," JGI users can more easily access public data sets. (Steve Wilson)
    A User-Centered Approach to Accessing JGI Data
    Reflecting a structural shift in data access, the JGI Data Portal offers a way for users to more easily access public data sets through a common set of metadata.

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    Phytozome portal collage
    A More Intuitive Phytozome Interface
    Phytozome v13 now hosts upwards of 250 plant genomes and provides users with the genome browsers, gene pages, search, BLAST and BioMart data warehouse interfaces they have come to rely on, with a more intuitive interface.

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    screencap from Amundson and Wilkins subsurface microbiome video
    Digging into Microbial Ecosystems Deep Underground
    JGI users and microbiome researchers at Colorado State University have many questions about the microbial communities deep underground, including the role viral infection may play in other natural ecosystems.

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    Yeast strains engineered for the biochemical conversion of glucose to value-added products are limited in chemical output due to growth and viability constraints. Cell extracts provide an alternative format for chemical synthesis in the absence of cell growth by isolating the soluble components of lysed cells. By separating the production of enzymes (during growth) and the biochemical production process (in cell-free reactions), this framework enables biosynthesis of diverse chemical products at volumetric productivities greater than the source strains. (Blake Rasor)
    Boosting Small Molecule Production in Super “Soup”
    Researchers supported through the Emerging Technologies Opportunity Program describe a two-pronged approach that starts with engineered yeast cells but then moves out of the cell structure into a cell-free system.

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    These bright green spots are fluorescently labelled bacteria from soil collected from the surface of plant roots. For reference, the scale bar at bottom right is 10 micrometers long. (Rhona Stuart)
    A Powerful Technique to Study Microbes, Now Easier
    In JGI's Genome Insider podcast: LLNL biologist Jennifer Pett-Ridge collaborated with JGI scientists through the Emerging Technologies Opportunity Program to semi-automate experiments that measure microbial activity in soil.

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    A view of the mangroves from which the giant bacteria were sampled in Guadeloupe. (Hugo Bret)
    Giant Bacteria Found in Guadeloupe Mangroves Challenge Traditional Concepts
    Harnessing JGI and Berkeley Lab resources, researchers characterized a giant - 5,000 times bigger than most bacteria - filamentous bacterium discovered in the Caribbean mangroves.

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    In their approved proposal, Frederick Colwell of Oregon State University and colleagues are interested in the microbial communities that live on Alaska’s glacially dominated Copper River Delta. They’re looking at how the microbes in these high latitude wetlands, such as the Copper River Delta wetland pond shown here, cycle carbon. (Courtesy of Rick Colwell)
    Monitoring Inter-Organism Interactions Within Ecosystems
    Many of the proposals approved through JGI's annual Community Science Program call focus on harnessing genomics to developing sustainable resources for biofuels and bioproducts.

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    Coloring the water, the algae Phaeocystis blooms off the side of the sampling vessel, Polarstern, in the temperate region of the North Atlantic. (Katrin Schmidt)
    Climate Change Threatens Base of Polar Oceans’ Bountiful Food Webs
    As warm-adapted microbes edge polewards, they’d oust resident tiny algae. It's a trend that threatens to destabilize the delicate marine food web and change the oceans as we know them.

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Home › Items tagged with: Eddy Rubin

Content Tagged "Eddy Rubin"

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January 27, 2011

Cow rumen metagenome study in Scientific American

“If the industry is going to move forward, it’s going to need new enzymes,” says Eddy Rubin, the director of the U.S. Department of Energy’s Joint Genome Institute. Rubin and 16 colleagues report in the January 28 issue of Science how they discovered nearly 30,000 new enzyme candidates by analyzing DNA collected from a cow’s… [Read More]

January 27, 2011

Cow rumen metagenome study on EurekAlert

“Microbes have evolved over millions of years to efficiently degrade recalcitrant biomass,” said Eddy Rubin, Director of the JGI and a lead on this study. “Communities of these organisms can be found in diverse ecosystems, such as in the rumen of cows, the guts of termites, in compost piles, as well as covering the forest… [Read More]

January 27, 2011

Cow rumen metagenome study in This Week in Science

Identification of additional enzymes that can degrade cellulose efficiently should help in the development of biofuels on an industrial scale. Uncultured microorganisms living in cow rumen are highly effective at degrading plant cell walls. Hess et al. used metagenomics and single-genome sequencing to assemble draft genomes from microbes adhering to rumen-incubated switchgrass to identify nearly… [Read More]

December 17, 2010

DOE JGI in Science’s Insights of the Decade

Edward Rubin and Len Pennacchio of the Joint Genome Institute in Walnut Creek, California, and colleagues figured out that some of this conserved DNA helps regulate genes, sometimes from afar, by testing it for function in transgenic mouse embryos. Studies by the group and others suggested that noncoding regions were littered with much more regulatory… [Read More]

December 17, 2010

Making Science’s Insights of the Decade list – twice

The December 17 issue of Science includes a special feature called “Insights of the Decade” and two of them feature work done by DOE JGI researchers. (Note: Free registration is required to read the articles online.) Genome research features prominently in Science’s Insights of the Decade list. (DNA helix image by DS from Flickr via… [Read More]

May 24, 2010

JGI CIO announcement on HPC Wire

The Director of the Joint Genome Institute (JGI), Eddy Rubin, has announced that Victor Markowitz will serve as the new Chief Informatics Officer and Associate Director at JGI effective May 17, 2010. Read more on HPC Wire. [Read More]

May 24, 2010

JGI CIO announcement on GenomeWeb

Markowitz will continue to lead the Biological Data Management and Technology Center while serving as a member of JGI’s senior management team, with responsibilities that include advising Director Eddy Rubin on issues concerning JGI’s technology infrastructure, how it can best be used, and what new equipment will be needed in the future. Read more on… [Read More]

May 9, 2010

Eddy Rubin and Neanderthal genome on SF Chronicle

Edward M. “Eddy” Rubin, director of the Department of Energy’s Joint Genome Institute in Walnut Creek, called the major project “a terrific piece of work and a monumental endeavor,” The project’s scientists used tiny specks of powdered bone retrieved from three Neanderthal females who died in a Croatian cave more than 40,000 years ago to… [Read More]

January 4, 2010

GEBA project on Press Trust of India

A preview of the initial “volume” of the Genomic Encyclopedia of Bacteria and Archaea (GEBA), which was published by the Department of Energy Joint Genome Institute (DOE JGI), has recently appeared in journal Nature. The report presented an analysis of the first 56 genomes representing two of the three domains of the tree of life…. [Read More]

October 2, 2009

T. reesei research a DOE National Impact story

In 2008, scientists funded in part by the U.S. Department of Energy (DOE) Office of Science at the DOE Joint Genome Institute (JGI) mapped the genome of this important organism using the Army reference strain. According to Eddy Rubin, DOE JGI Director in 2008 interview, “the genome of T. reesei provides us with a roadmap… [Read More]
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