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    Screencap of green algae video for PNAS paper
    Green Algae Reveal One mRNA Encodes Many Proteins
    A team of researchers has found numerous examples of polycistronic expression – in which two or more genes are encoded on a single molecule of mRNA – in two species of green algae.

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    Advances in Rapidly Engineering Non-model Bacteria
    CRAGE is a technique for chassis (or strain)-independent recombinase-assisted genome engineering, allowing scientists to conduct genome-wide screens and explore biosynthetic pathways. Now, CRAGE is being applied to other synthetic biology problems.

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    Maize can produce a cocktail of antibiotics with a handful of enzymes. (Sam Fentress, CC BY-SA 2.0)
    How Maize Makes An Antibiotic Cocktail
    Zealexins are produced in every corn variety and protect maize by fending off fungal and microbial infections using surprisingly few enzymes.

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    Poplar (Populus trichocarpa and P. deltoides) grow in the Advanced Plant Phenotyping Laboratory (APPL) at Oak Ridge National Laboratory in Tennessee. Poplar is an important biofuel feedstock, and Populus trichocarpa is the first tree species to have its genome sequenced — a feat accomplished by JGI. (Image courtesy of Oak Ridge National Laboratory, U.S. Dept. of Energy)
    Podcast: Xiaohan Yang on A Plantiful Future
    Building off plant genomics collaborations between the JGI and Oak Ridge National Laboratory, Xiaohan Yang envisions customizing plants for the benefit of human society.

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    Expansin complex with cell wall in background. (Courtesy of Daniel Cosgrove)
    Synthesizing Microbial Expansins with Unusual Activities
    Expansin proteins from diverse microbes have potential uses in deconstructing lignocellulosic biomass for conversion to renewable biofuels, nanocellulosic fibers, and commodity biochemicals.

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    High oleic pennycress. (Courtesy of Ratan Chopra)
    Pennycress – A Solution for Global Food Security, Renewable Energy and Ecosystem Benefits
    Pennycress (Thlaspi arvense) is under development as a winter annual oilseed bioenergy crop. It could produce up to 3 billion gallons of seed oil annually while reducing soil erosion and fertilizer runoff.

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    Artistic interpretation of CheckV assessing virus genome sequences from environmental samples. (Rendered by Zosia Rostomian​, Berkeley Lab)
    An Automated Tool for Assessing Virus Data Quality
    CheckV can be broadly utilized by the research community to gauge virus data quality and will help researchers to follow best practices and guidelines for providing the minimum amount of information for an uncultivated virus genome.

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    Unicellular algae in the Chlorella genus, magnified 1300x. (Andrei Savitsky)
    A One-Stop Shop for Analyzing Algal Genomes
    The PhycoCosm data portal is an interactive browser that allows algal scientists and enthusiasts to look deep into more than 100 algal genomes, compare them, and visualize supporting experimental data.

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    Artistic interpretation of how microbial genome sequences from the GEM catalog can help fill in gaps of knowledge about the microbes that play key roles in the Earth's microbiomes. (Rendered by Zosia Rostomian​, Berkeley Lab)
    Podcast: A Primer on Genome Mining
    In Natural Prodcast: the basics of genome mining, and how JGI researchers conducted it in IMG/ABC on thousands of metagenome-derived genomes for a Nature Biotechnology paper.

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    Image of Octopus Springs for the CSP annual call
    Letters of Intent are due April 12, 2021 for the annual Community Science Program (CSP) call focused on large-scale genomic science projects that address specific areas of special emphasis and exploit the diversity of JGI capabilities.

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    SIP engagement webinar
    “SIP technologies at EMSL and JGI” Webinar
    The concerted stable isotope-related tools and resources of the JGI and the Environmental Molecular Sciences Laboratory (EMSL) may be requested by applying for the annual “Facilities Integrating Collaborations for User Science” (FICUS) call.

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    CSP Functional Genomics Call Ongoing
    The CSP Functional Genomics call helps users translate genomic information into biological function. Proposals submitted by July 31, 2021 will be part of the next review.

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    Aerial photo of the switchgrass diversity panel late in the 2020 season at the Kellogg Biological Station in Michigan. (Robert Goodwin)
    A Team Effort Toward Targeted Crop Improvements
    A multi-institutional team has produced a high-quality reference sequence of the complex switchgrass genome. Building off this work, researchers at three DOE Bioenergy Research Centers have expanded the network of common gardens and are exploring improvements to switchgrass.

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    Artistic interpretation of how microbial genome sequences from the GEM catalog can help fill in gaps of knowledge about the microbes that play key roles in the Earth's microbiomes. (Rendered by Zosia Rostomian​, Berkeley Lab)
    Uncovering Novel Genomes from Earth’s Microbiomes
    A public repository of 52,515 microbial draft genomes generated from environmental samples around the world, expanding the known diversity of bacteria and archaea by 44%, is now available .

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    Green millet (Setaria viridis) plant collected in the wild. (Courtesy of the Kellogg lab)
    Shattering Expectations: Novel Seed Dispersal Gene Found in Green Millet
    In Nature Biotechnology, a very high quality reference Setaria viridis genome was sequenced, and for the first time in wild populations, a gene related to seed dispersal was identified.

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Home › Our Science › Scientists at JGI › Igor Grigoriev

Igor Grigoriev

grigoriev

Igor Grigoriev, Ph.D
Fungal Genomics Program Lead, DOE Joint Genome Institute

Following postdoctoral training and several years of work in the pharmaceutical industry, Dr. Grigoriev joined the DOE Joint Genome Institute in 2003 to participate in human genome annotation and lead annotation of over 100 diverse eukaryotic genomes from protists to plants. In 2009, he started the Fungal Genomics program to scale up sequencing and analysis of diverse fungi for related to DOE science and applications. Dr. Grigoriev organized over 30 genomics workshops and engaged over 2000 researchers around the world in genome projects, which resulted in over 50 high-profile publications. In the same vein, he and his team are working to organize research labs around large-scale, most-needed genomics projects to develop genetic blueprints for diverse algae to enable comparative and functional algal genomics.

Education

  • BA/MS in Biophysics, Moscow Engineering Physics Institute, Moscow, Russia
  • PhD in Molecular Biology, Research Institute for Genetics and Selection of Industrial Organisms, Moscow, Russia
  • Postdoctoral training in computational structural genomics, University of California, Berkeley, CA

Selected Publications

  1. Riley et al (2016) Comparative genomics of biotechnologically important yeasts. Proc Natl Acad Sci U S A. 113(35):9882-7.
  2. Corrochano et al  (2016) Expansion of signal transduction pathways in fungi by extensive genome duplication. Curr Biol. 26(12):1577-1584.
  3. Dhillon et al (2015) Horizontal gene transfer and gene dosage drives adaptation to wood colonization in a tree pathogen. Proc Natl Acad Sci U S A. 112(11):3451-3456.
  4. Kohler et al  (2015) Convergent losses of decay mechanisms and rapid turnover of symbiosis genes in mycorrhizal mutualists. Nature Genet. 47(4):410-415.
  5. Grigoriev et al (2014) MycoCosm portal: gearing up for 1000 fungal genomes. Nucleic Acids Res.42(1):D699-704.
  6. Riley R et al. Extensive sampling of basidiomycete genomes demonstrates inadequacy of the white-rot/brown-rot paradigm for wood decay fungi. Proc Natl Acad Sci U S A. 2014; 111: 9923-9928.
  7. Tisserant E et al.  Genome of an arbuscular mycorrhizal fungus provides insight into the oldest plant symbiosis. Proc Natl Acad Sci U S A. 2013; 110: 20117-20122.
  8. Read B et al. Pan genome of the phytoplankton Emiliania underpins its global distribution. Nature. 2013; 499: 209-213.
  9. Curtis BA Algal genomes reveal evolutionary mosaicism and the fate of nucleomorphs. Nature. 2012; 492: 59-65.
  10. Ohm RA et al. Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen dothideomycetes fungi. PLoS Pathog. 2012; 8(12):e1003037.
  11. Floudas D et al. The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes. Science. 2012;336: 1715-1719.
  12. Berka RM et al. Comparative genomic analysis of the thermophilic biomass-degrading fungi Myceliophthora thermophila and Thielavia terrestris. Nat Biotechnol. 2011; 29: 922-927.
  13. Eastwood DC et al. The plant cell wall-decomposing machinery underlies the functional diversity of forest fungi. Science. 2011; 333: 762-765.
  14. Gobler CJ et al. Niche of harmful alga Aureococcus anophagefferens revealed through ecogenomics. Proc Natl Acad Sci U S A. 2011; 108: 4352-4357.
  15. Banks JA et al. The Selaginella Genome Identifies Genetic Changes Associated with the Evolution of Vascular Plants. Science, 2011; 332: 960-963.
  16. Colbourne JK et al. The ecoresponsive genome of Daphnia pulex. Science. 2011; 331: 555-561.
  17. Ohm RA et al. Formation of mushrooms and lignocellulose degradation encoded in the genome sequence of Schizophyllum commune. Nat Biotech. 2010; 28: 957-963.
  18. Worden AZ et al. Green evolution and dynamic adaptations revealed by genomes of the marine picoeukaryotes Micromonas. Science. 2009; 324: 268-272.
  19. Bowler C et al. The Phaeodactylum genome reveals the dynamic nature and multi-lineage evolutionary history of diatom genomes. Nature. 2008; 456: 239-244.
  20. Martin F et al. The genome of Laccaria bicolor provides insights into mycorrhizal symbiosis. Nature. 2008; 452: 88-92.
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