Regulation of the expression of the apolipoprotein(a) gene – Evidence for a regulatory role of the 5 ‘ distal apolipoprotein(a) transcription control region enhancer in yeast artificial chromosome transgenic mice
Objective-The apolipoprotein(a) [apo(a)] gene locus is the major determinant of the circulating concentration of the atherothrombogenic lipoprotein Lp(a). In vitro analysis of the intergenic region between the apo(a) and plasminogen genes revealed the presence of a putative apo(a) transcription control region (ACR) approximately 20 kb upstream of the apo(a) gene that significantly increases the minimal… [Read More]