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… of secondary metabolism. Welcome back. This will be episode 12 of Natural Prodcast. And it’s our conversation with … Europe. So if there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And I think you’ll enjoy it. So here it is, episode 12 with Nadine Ziemert. DAN UDWARY: Hey, Alison. ALISON …

Search for your proposal using your proposal's WIP ID (ex. 503582). Click on the correct proposal name on your search … Department of Energy operated under Contract No. DE-AC02-05CH11231.” … All publications using JGI data produced under a …

… as well as a unique opportunity to complete a California K-12 science or math teaching credential as an undergraduate …

And you have these different types of particulate like 2.5, 10 PPMs and just the size of the particle and how far … there a way to do that? DAN UDWARY: Well, so there’s good news and bad news on that. So one of the things that we’re … happening. And so we should have somewhere around 10, 11, 12 million BGCs in the database on the release, and that’s …

… because they’re so reactive. BEN: …going back to the 1950s. But the structure of which was not known until the … right? BEN: Yeah, yeah. Well, we are at [10 to the] minus 12 [Molar concentration]- is sufficient to kill cells. So … So I wanted to ask you also about – because you were in the news recently – TSRI has acquired the Pfizer strain …

… out where I got the chance to do genome mining on more than 50,000 genomes that we derived from meta-genome sequences. … in Yu et al, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2004, 1253–1262, 70:3 ALISON TAKEMURA: And so did you succeed in … Microbiomes” paper is here . Read the associated JGI news release here . Software we discussed, used for genome …

… within the realm of education. … Through the Berkeley Lab K-12 program, the JGI collaborates with Biotech Partners to …

Adopt-a-Genome has:  11 CSU educators working with the JGI 120 genomes claimed (or about one per student) Seven … and publicly available datasets encompassing >150,000 isolate genomes, 230,000 metagenome-assembled genomes … entomopathogenic nematodes: Xenorhabdus cabanillasii DSM17905, Xenorhabdus ehlersii DSM16337, Xenorhabdus japonica …

… box of protective tricks. Nature Reviews Microbiology 20 (5), 255-255 Schulz et al. (2020) Giant virus diversity and host …

… never forced it on me, but we always had these scientific news magazines lying around at home. And I would just pick … was bioengineering bio-process R&D, BBRD, a group of about 75 people. So our biggest project was the spinosyn family of … takes about 10 years. Costs are in the range of $100 to $120 million to do that.  DAN: OK. So about the same amount …

… access to the whole sigma catalog of precursors in their 12C form. You can feed those and look for incorporation in … would grow up our bacteria on 13C methane or methanol, feed 12C methionine, and we were able to pull out the quorum … source and the other with 13C carbon source plus your 12C precursor. You look for a shift of four. Boom. It works …