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Extracting the Secrets of Secondary Metabolites
… (Clustered Regularly Interspaced Short Palindromic Repeats) is the leading tool for accurately editing genomes, its … the functions of the biosynthetic gene clusters that produce them. The Impact Secondary metabolites are microbial … the U.S. Department of Energy (DOE) Joint Genome Institute (JGI), a DOE Office of Science User Facility located at …
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A Pinch of Salt Activates Silent Gene Clusters in Streptomyces
… multiple omics methods to examine microbial chemical production. The Science Soil bacteria in the genus Streptomyces are nature's chemical factories. They hold genetic blueprints for … of multiple omics data from various environments — that JGI users can leverage to create a more complete picture of …
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2025 Progress Report
… JGI researchers demonstrate how their laboratory and data science efforts support users, advance foundational …
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A Community Resource for Secondary Metabolite Researchers
… The Secondary Metabolism Collaboratory encourages user engagement. The Science In addition to … by most living creatures for energy, growth and reproduction—most organisms produce a set of "secondary … The U.S. Department of Energy (DOE) Joint Genome Institute (JGI), a DOE Office of Science User Facility located at …
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Mapping Heat Resistance in Yeasts
… A new approach for improving functional annotation in fungal genomes. The Science In a proof-of-concept … across very distant species that no longer mate to produce progeny. The ability to pinpoint which genes underlie … Genomics Project led by the DOE Joint Genome Institute (JGI), a DOE Office of Science User Facility of Lawrence …
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An Enzyme Family that Helped Shape Nitrogen Metabolism on Our Planet
… Researchers looked across many organisms to see that aminotransferase enzymes have evolved mix-and-match … leaving potential targets for crop engineering untouched. Research recently published in  The Proceedings of … the U.S. Department of Energy (DOE) Joint Genome Institute (JGI), a DOE Office of Science User Facility located at …
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The Power of One, Amplified
… metagenomics studies. The Science Researchers demonstrated the value of conducting large-scale single cell genomics by collecting nearly … the U.S. Department of Energy (DOE) Joint Genome Institute (JGI), a DOE Office of Science User Facility located at … DE-AC02-05CH11231. This work was supported in part by a Natural Sciences and Energy Research Council of Canada …
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Iron-rich Microbial Mats’ Main Players: Marsarchaeota
… in early Earth conditions. The Science Through a combination of sequencing tools and techniques applied to samples … into the evolution of life on Earth. For decades, longtime JGI collaborator Bill Inskeep of Montana State University has been conducting microbial field studies at Yellowstone, and in this …
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The Surprising Structure of a Shrub Willow Sex Chromosome
… A genetic architecture that is characteristic of the sex chromosomes of mammals is, … sequenced with sufficient resolution to analyze their structure. Scientists found both a gene likely important for … the U.S. Department of Energy (DOE) Joint Genome Institute (JGI), a DOE Office of Science User Facility located at …
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How Maize Makes An Antibiotic Cocktail
… Maize produces a family of compounds that protects it against … as  Sorghum bicolor — a  candidate bioenergy feedstock and  JGI Flagship Plant — could produce at least 15 zealexins. … by a DOE Joint Genome Institute Community Science Program (JGI-CSP) grant (CSP2568 to P.Z., ES and AH), and by a …
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From Stress to Growth: The adaptive mechanisms of algae in changing Arctic waters
… P. psychrophila genes drive resilience when salinity fluctuates. The Science The Arctic microalga Plocamiomonas … the U.S. Department of Energy (DOE) Joint Genome Institute (JGI), a DOE Office of Science User Facility located at … The study was funded by Natural Sciences and Engineering Research Council of Canada …
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Defining a Pan-Genome for Antarctic Archaea
… Antarctic lakes, some of which have salinities 10 times that of seawater. To shed light on the global biogeography in … regional and global biogeography of haloarchaea and the structure and extent of the Antarctic microbial pan-genome. … applications. The work has been enabled through the JGI Community Science Program (CSP) . Cavicchioli and his …
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