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Scaling Up Existing Skill Sets
… of the internship, 4th year PhD student in Quantitative and Systems Biology Mentor: Guohong Wu, Plant Comparative Analysis What … Class Year: 2nd year graduate student in Quantitative and Systems Biology Mentor: Ernst Oberortner, Functional …
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Giant Bacteria Found in Guadeloupe Mangroves Challenge Traditional Concepts
… (Berkeley Lab) and the Laboratory for Research in Complex Systems (LRC) in Menlo Park, Calif. In the June 24, 2022, … bacterium itself was discovered by Olivier Gros, a marine biology professor at the Université des Antilles in … level. They amplified, sequenced and assembled the genomes. In parallel, Gros’ lab also used a labeling …
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An Age of CRAGE: Advances in Rapidly Engineering Non-model Bacteria
… that allows researchers to quickly modify diverse bacterial genomes. In 2019, the JGI’s Yasuo Yoshikuni and his team  announced in  Nature Microbiology an important addition to the synthetic biologist’s … technique CRAGE lands the cover of ACS Synthetic Biology. (Wayne Keefe/Berkeley Lab) For example, the JGI …
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DAS Tool for Genome Reconstruction from Metagenomes
… an integrated approach to genome recovery from metagenomes. The Science Through the JGI’s Emerging Technologies … algorithms, allowing them to reconstruct more near-complete genomes from soil metagenomes compared to other methods. The … and environmental scientific challenges. In Nature Microbiology , a team led by longtime JGI collaborator Jill …
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Leo Baumgart
… in 2018, following his doctoral research in synthetic biology and microfluidics at the University of California, … BS in Biochemistry and Cell Biology, University of California, San Diego PhD in Molecular Biology, University of California, San Diego Postdoctoral …
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A Redesign for Yeast’s Genome, Chromosome by Chromosome
… To engineer yeast to do more, and understand genomes in general, Jef Boeke, Weimin Zhang (NYU Langone …
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Fungal Friends or Foes in Plant Roots
… plant host health. The Science Researchers compared the genomes of fungi that colonize Arabidopsis thaliana roots with genomes from other plant-associated fungi. Their analysis … gaps on the fungal Tree of Life through the 1000 Fungal Genomes Project. Hacquard’s group had assembled a mycobiome …
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A Revamped Amplification Method that Enables Nearly Complete Single-Cell Genomes
… results from single cells. The Science Studying the  genomes of microorganisms is incredibly useful for … most species do not grow easily in the lab. To access the genomes of uncultured  microbes , scientists usually employ … method called Multiple Displacement Amplification, and most genomes that were acquired through it were usually only …
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Applying Viral Genomics Expertise to Understanding the Human Virome
… workflows that allow researchers to easily analyze viral genomes. This includes (i) classifying viruses into groups … the quality and completeness of metagenome-assembled viral genomes ( Nature Biotechnology , 2021), geNomad , a tool for … robust methodologies for analyzing and understanding viral genomes and their interactions with microbial hosts. The …
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Boosting Small Molecule Production in Super “Soup”
… would be transformative at industrial scales. “Cell-free systems have been really powerful at finding ways to … “But this has been done most commonly in bacterial-based systems, and so one of the things that I think is so special … “This is a fantastic example of rapid-prototyping systems for metabolic pathways that we plan to offer to …
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Axel Visel
… for elucidating the gene regulatory landscape of vertebrate genomes, which led to the discovery of thousands of genetic … Board) , Cell Reports, Nature Structural and Molecular Biology, PLoS Computational Biology , Nucleic Acids Research . Over 80 publications in peer-reviewed journals including Nature, …
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Fishing for Novel Cellulose Degraders
… To validate the predicted cellulases from their captured genomes, the team then used DNA synthesis and cloning, … form of functional enrichment leading to the sequencing of genomes from either individual cells or consortia of cells,” …
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