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… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … is always associated with toxicity, basically, killing cells. ALISON: Right, because they’re so reactive. BEN: … how nature is making compounds, but we are also applying CRISPR technology, anything as genome editing, genome …

… of a cave. So it just– it really, really, really falls rapidly. But we eventually– after testing all these … mammalian systems. But it allows us to assay on a single cell level against cell lines and against primary cells … So you can knock out an acyltransferase and then use a free hydroxyl group and do some chemistry and get around …

Micro-Scale Applications group explores the genetic makeup of natural microbial communities using a variety of … technology in order to enhance the quality of single-cell genomes and directly link functional information with individual cells. Research Team    … The JGI uniquely offers the first …

… for researchers to request the capabilities and expertise of multiple DOE National User Facilities in one research … provides customized analysis, the JGI also participates in publication of results. … Proposals for the annual FICUS …

Guiding Principles All staff members of the US Department of Energy (DOE) Joint Genome Institute … we can foster a respectful, collaborative environment free of harassment. To uphold Berkeley Lab’s enduring … ecosystem. Their trust hinges on sustaining our record of excellence and respect, and for principles of integrity, …

… been described in such detail. DAN UDWARY: Alison, feel free to jump in with questions. But otherwise I’m going to … that the molecules out there would be toxic to cancer cells. And that started something big. Because at that time, … normal cells, particularly your hair cells, which are also rapidly growing, the cells in the mucosa lining of your …

Software engineers in the Synthetic Biology Informatics Group develop, deploy, and maintain software that support the JGI’s Synthetic Biology Program .  … software includes: gRNA-SeqRET , an organism-agnostic CRISPR gRNA design tool BOOST , which provides a suite of …

… works closely with the Berkeley Lab Intellectual Property Office to facilitate these new interactions.  The PDT … Area to quantify atmospheric gas mitigation properties of multiple rice plant growth promotion technologies using … pathways. The team will be working with LanzaTech to rapidly engineer a Clostridium strain for the production of …

… (BGCs), advancing pathway analysis, optimization of cell- and cell free-based expression platforms, tools and data for … of secondary metabolites and improving the tools for their characterization, the program strives to facilitate the …

DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast, a … and how we do it here and maybe give an example of a recent publication. ALISON TAKEMURA: Awesome. Yeah, let’s dive in, … and store. They’re easy to grow up, easy to throw in a freezer. Most of the successful genome mining has been in …

… on genomic science projects that address sustainable biofuel and bioproducts production, leveraging systems-based approaches to unravel functional capabilities of plants, microbes and microbial communities, global carbon … and nutrient cycling, and biogeochemistry — questions of relevance to DOE’s Office of Biological and Environmental …

… recognize this material, though my show is a little more free-form, and this is the longer cut of the discussions you … molecules obviously play a huge role in ecology through cell-cell communication, chemical warfare, and symbiotic … do the bioinformatics and to synthesize these results into publication? So there’s this really important because we …