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… great conversations that we’ve already recorded with some excellent scientists, and that’s probably how we’ll continue … right. So I did a PhD in microbiology at MIT, and I studied microbial ecology. I studied Vibrio species in the ocean, so heterotrophic bacteria. Now, we didn’t get into …

… for example, in terms of the stereochemistry, such that single changes can lead to a particular high activity … move a little bit away from that to try to unmask chemical dark matter. And the idea behind this is that, if we … UGA-Langebio in Irapuato, Mexico. His interests are in microbial diversity and evolution, particularly as how …

… in environmental sequence data. We use multi-omics (metagenomics, metatranscriptomics, single cell genomics and phylogenomics) and machine learning to …

… streams. This will all become clearer as we get into the genomics. So– ALISON TAKEMURA: I’m just enjoying the ride … know nothing about biology. Biology hates us. It’s a little dark, but. [laughs] DAN UDWARY: Yep. ALISON TAKEMURA: It’s … of the IMG data portal , which is a larger portal for microbial genomics. IMG stands for Integrated Microbial …

… 2009, researchers at the JGI and the Bigelow Laboratory for Ocean Sciences described a novel technique to access … and offered a way for researchers to study the planet’s microbial diversity, much of which remains unknown and … of key microbial culprits in carbon fixation in the dark ocean. Combining single cell genomics and synthetic …

… are complex organisms that harbor a fantastic diversity of cell types and associated organisms, including fungal and bacterial symbionts, detrimental microbial pathogens, and associated viruses that all … genomics-powered tools to study this complexity, including single-cell and spatial transcriptomics barcode-based …

Brad Moore, UC San Diego and Scripps Institution of Oceanography. (Courtesy of B. Moore) DAN: This is the second … the mid-late ’80s. And at that time, you know, it’s before genomics existed. This is before we’re even thinking of … of, better understand fundamentally what’s going on in the cell as it responds to its ocean environment. And as we …

… is always associated with toxicity, basically, killing cells. ALISON: Right, because they’re so reactive. BEN: … genomic revolution, to me, as a natural part chemist for microbial natural product, is that I love microbial natural … DAN: Yeah, I don’t think your lab is gonna tackle that single handedly, right? So, yeah, getting the community …

… come, though, too when you start talking about going after single gene clusters. BRIAN BACHMANN: That’s right. JACKIE … of thought with that. So some people are interested in cave microbial– people are interested in the more extreme … mammalian systems. But it allows us to assay on a single cell level against cell lines and against primary cells …

Accessing Resources at Multiple DOE User Facilities with a Single Proposal describes the resources available from the … samples of the spatial, temporal, taxonomic (environmental, microbial, plants, invertebrate, and vertebrate), and …

… and ecosystems at the molecular level. Integrating genomics with metabolomics fuels the discovery  of novel … exploration of energy and nutrient exchange, as well as microbial and plant responses to environmental changes. With … systems can provide novel insights into the impact of microbial symbionts and their hosts on ecosystems.   …

… to unravel functional capabilities of plants, microbes and microbial communities, global carbon and nutrient cycling, …