Search

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … families we talk a lot about in this interview are the RiPPs, which stands for “Ribosomally synthesized and … way of making proteins, with a ribosome. Then, some other enzymes chop the protein into smaller pieces, and other …

… The purpose of this policy is to establish communication norms around JGI contributions, ensure that all … that the data produced by the facility result in scientific publications. JGI users and collaborators have the right to … JGI staff will provide Users with a list of contributors and their corresponding ORCiD and relevant CRediT …

… as exploring and exploiting biocatalysts – that is, using enzymes to do chemical reactions. Obviously, in my work, in … not. And so the question of do you need something that’s promiscuous for it to be useful? Not in a process chemistry … and substrate specificity, but when you kind of are applying them to making a compound, do you also take into …

… DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s Natural … and how we do it here and maybe give an example of a recent publication. ALISON TAKEMURA: Awesome. Yeah, let’s dive in, … non-ribosomal peptides. It’ll find all of your terpenes and RiPPs and all kinds of other things that are even more …

… DAN: All right. Welcome back to Natural Prodcast. I did it. I’m keeping to my schedule. … But on the other hand, we're also really interested in enzymes to do some of the reactions that chemists find … be. And so we are specifically looking at non-ribosomal peptides, looking in genomes for ones that are cyclic. And …

… now I’m working on this the afternoon of the day I’m due to release it, which is not ideal for me keeping myself on … It was actually originally predicted to be a nonribosomal peptide synthetase but then flanked by these two genes that … lactone based systems. So you have these synthase enzymes that can make the signal. You have the signal …

… “Adopt a Genome” is an informal program for faculty to “claim” the … faculty will work with undergraduates in the analysis and publication of the claimed genome sequences. This … A primary purpose of this project is to bring educators from a broad range of disciplines …

… DAN UDWARY: You’re listening to the Department of Energy Joint … will be very flexible. They will allow promiscuity and the enzymes are driving the production of these compounds, … Episode Transcript … of natural product biosynthesis in bacteria ” The ActDES publication came out after we talked. It looks like a great …

… as something like scientific cousins. So we both went to Scripps [Institution of Oceanography in San Diego] together. … Usually, in a lot of cases, we still have to go through publications to get proteins, and their functions, and all … And then you search for – re-search for these biosynthetic enzymes that we think must be similar within the fosmid …

… The Facilities Integrating Collaborations for User Science (FICUS) call represents a unique opportunity for researchers to request the capabilities and expertise of multiple DOE … provides customized analysis, the JGI also participates in publication of results. …