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… of secondary metabolism. Welcome back. This will be episode 12 of Natural Prodcast. And it’s our conversation with … Europe. So if there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And … in the early 2000s? Late 2000s? NADINE ZIEMERT: No, yeah, 2010. ALISON TAKEMURA: 2010, OK. You’re a young faculty. …

… getting them out to you all. But for now, here is episode 10 of Natural Prodcast, the primer on genome mining. Hey, … in Yu et al, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2004, 1253–1262, 70:3 ALISON TAKEMURA: And so did you succeed … Microbiomes” paper is here . Read the associated JGI news release here . Software we discussed, used for genome …

… of Energy Joint Genome Institute ( https://ror.org/04xm1d337 ), a DOE Office of Science User Facility, is … of Energy operated under Contract No. DE-AC02-05CH11231.” … All publications using JGI data produced under a … of Energy Joint Genome Institute ( https://ror.org/04xm1d337 ), a DOE Office of Science User Facility, is …

Adopt-a-Genome has:  11 CSU educators working with the JGI 120 genomes claimed (or about one per student) Seven … al.  2023 . Microbiology Resource Announcements. 2023 12 (10), e00548-23 Whole genome sequence of the denitrifying … Announc. Genome sequence of  Dysgonomonas hofstadii  DSM 104969 Isolated from a human abdominal surgery wound. V. …

And you have these different types of particulate like 2.5, 10 PPMs and just the size of the particle and how far they … there a way to do that? DAN UDWARY: Well, so there’s good news and bad news on that. So one of the things that we’re … happening. And so we should have somewhere around 10, 11, 12 million BGCs in the database on the release, and that’s …

… as well as a unique opportunity to complete a California K-12 science or math teaching credential as an undergraduate …

So they’re in the picomolar range. ALISON: Picomole… is [10 to the] minus twelve, right? BEN: Yeah, yeah. Well, we are at [10 to the] minus 12 [Molar concentration]- is sufficient to kill cells. So … So I wanted to ask you also about – because you were in the news recently – TSRI has acquired the Pfizer strain …

… people what that number is. BETSY PARKINSON: So micromolar, 10 to the negative 6th. Nanomolar, 10 to the negative 9th. Picomolar, 10 to the negative 12th. DAN: Yeah. So very-- BETSY PARKINSON: Very, very-- …

… goal to have 1,000 women in the program over a span of 10 years. So typically about 80 to 100 women get selected each year as a cohort to experience this 12-months leadership program, of which the last month is in …

… convince those people of that fact, however, a long time, 10 years! ALISON TAKEMURA: Wow. It’s all happened so fast. I … of the molecules in ecology. And that took another 10 years at least. But I had several students. And I worked … discovered this and it got developed in somewhere around 2004, I guess, something like that, and now, 2021, it doesn’t …

… never forced it on me, but we always had these scientific news magazines lying around at home. And I would just pick … had a high throughput screening platform where we’d look at 10,000, 15,000, 20,000 mutants a week. We started doing a … takes about 10 years. Costs are in the range of $100 to $120 million to do that.  DAN: OK. So about the same amount …