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… in the early 2000s called Ecopia, which was a very early genome mining company, back when DNA sequencing of natural … Yeah, that makes two of us. DAN UDWARY: So the audio quality was terrible. The hardware I was using was terrible. … And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really …

… exposure to working with Streptomyces, learning more about genome mining, as well as isolation and a little bit of … usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain … trans in order to cyclize at that small of a ring, which is highly unfavorable. DAN: Oh, I did not know that. That's …

… enzymes to do chemical reactions. Obviously, in my work, in genome mining, we have an awful lot of crossover, where us … And you want to have good binding to your substrate and high turnovers. But if you have those things, can you also … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh …

… products field as it relates to structure elucidation and genome mining, and how we might start to better connect … that most entries were looked at more at once, and so the quality – the data quality – was reasonably high. And yeah, it gave it gave us enough enough pairs of …

… more economic, they also would like to extract some high– what they term “high value–“ Dan Udwary: Right. Kate … been quite a lot of work in recent years to improve gender equality of people entering science programs. So actually, … is a whole bunch of information that maybe never makes its publication. And these are little tips, you know, how to …

… Facilities Integrating Collaborations for User Facilities (FICUS) program for fiscal year 2026, in partnership with the … user facilities. Focus areas for these projects include biofuels, biomaterials and bioproducts; hydrobiogeochemistry; … interorganismal interactions; and novel applications of molecular techniques. The FICUS program is designed to …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a podcast about the … sparked your interest, and you want to learn more, then I highly recommend David Hopwood’s book called  “Streptomyces … able to explore DNA sequencing and actually get to the DNA sequence – sequences for the genes that code for the …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very … and our collaborations to sequence that collection, mine genomes, and develop new technology to access natural …

… from NCI and other programs, we started showing real drug quality in [our] molecules. And that continued on for a … of Petri plates to watch what happens over time. And in the high-nutrient media, we saw all the same stuff, which are … So, this was when we started saying, we have to have the genomes. We have to look at the full picture of these. And …

… our Plant Program, and is further leveraging the services of the Arizona Genomics Institute for DNA and RNA … extractions to support plant and other efforts. The JGI works closely with DOE computational facilities (e.g., the … the Facilities Integrating Collaborations for User Science (FICUS) program.     …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have … This the second episode of Natural Prodcast, which continues a conversation from the …

… working in 21 fields.  Congratulations to the  2022 Highly Cited Researchers from the JGI recognized for their … influence in their chosen field or fields through the publication of multiple highly cited papers during the last … the JGI is sequencing thousands of bacterial and archaeal genomes from diverse branches of the Tree of Life.  Its …