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… been dominated for … well, as long as I can remember, by bacterial research.  So it was great to hear her passion and … on aflatoxin biosynthesis, aflatoxin being a secondary metabolite from an Aspergillus species that is pretty toxic … this one could be really good because, hey, it had a methyltransferase that changed. And, you know, I wish we could …

… this time. Let’s jump right in. — DAN: So secondary metabolites. I kind of inferred through the stories I told you about geosmin, which is a bacterial sacred metabolite, and ergot alkaloids come from … ALISON: Like such a large diversity can have similar effects, I think is also really interesting. Because …

… Program leads to discuss available options. Note: In 2021, we conducted an extensive internal product audit to … assembly), DGE, alignment files 91/126 Metabolomics Polar metabolite analysis Relative abundance profiling of polar (e.g. amino acids, nucleosides, etc) metabolites using normal phase chromatography coupled to …

… Secondary Metabolites User Advisory Committee …

… behave in certain solvents or certain reactions or mixtures temperature, do you do take that into account? Or do you and … proteins, I mean, what– from your perspective, like, what temperature would you want to push them to be able to still … organisms where their peak activity is at an elevated temperature. Right? We don’t necessarily see that the …

… R. Seshadri, M. Escobar. Draft genome sequences of two bacterial type strains isolated from a methanogenic … Draft genome sequences of three ruminant-associated Eubacteriales: Eubacterium ruminantium ATCC 17233T, … R. Seshadri, and C. Stephens. Genome sequences of key bacterial symbionts of entomopathogenic nematodes: …

… a check-up on me. And I wonder how that intersects with bacterial bioprospecting that is often done, where we’re … one thing we do see is that generally, the major secondary metabolites are there, they just are going to be there in … And we looked at both the chemistry and the pharmacological effects against bacteria.  And what was interesting is that …

… of years and relatively stable– no lights, constant temperature, constant humidity. And they were– so they were … terms of what we’re doing with the JGI with the Secondary Metabolites Collaboratory and trying to have a good catalog … could be called semisynthesis. So you can knock out an acyltransferase and then use a free hydroxyl group and do some …

… characterized.  Our metabolomics platform delivers rich metabolite profiles from diverse biological and …

… on an accelerated timeline as compared with the standard CSP projects. In addition, they must utilize a broad range … such as DNA-SIP, Protein SIP, Flux Balance analysis with metabolites, Isotope Ratio Mass Spectrometry, NanoSIMS, and …

… is focused on the discovery and characterization of novel bacterial, archaeal and eukaryotic microbes and viruses in … danicum gen. nov., sp. nov. in the ubiquitous bacterial phylum Patescibacteriota phyl. nov .”  ISME … all (2024) “ Adaptation strategies of giant viruses to low-temperature marine ecosystems .”  The ISME Journal , Volume …

… The Community Science Program (CSP) provides the scientific community at large with access … of disciplines. Three calls fall under the umbrella of our CSP: The Large Scale call is for expansive projects that …