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… the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very … genomic revolution, to me, as a natural part chemist for microbial natural product, is that I love microbial natural …

Analysis reveals the microbial community involved in a bioremediation effort. The … found its way into the groundwater of several communities in New Mexico via leakage from a local … and 2010. DNA was extracted from the samples that were sequenced by the U.S. Department of Energy (DOE) Joint …

… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean … IMG kind of hooks into IMG’s data. IMG being Integrated Microbial Genomics at JGI, a large data set of bacterial …

… week, we have our conversation with Professor Eric Schmidt, from the University of Utah. I’ve known Eric for a long time … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… is a bacterial sacred metabolite, and ergot alkaloids come from fungi, and Taxol from plants. Plants, fungi, bacteria, … DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … powerful people. These were people that really controlled microbial drug discovery. And a guy like me, with no … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …

Duncan: Yeah. I love actinomycetes. Dan Udwary: Tell us why. I mean, I know, but I think– Alison Takemura: I want to … of almost finished characterizing them. We’ve got genome sequences, which are just incredible. We’ve looked at the … And sometimes, in terms of biological activities– like antimicrobial or something– sometimes a little difference is …

The Facilities Integrating Collaborations for User Science … FICUS call with EMSL begin with a Letter of Intent (LOI) from a researcher, briefly describing the project … samples of the spatial, temporal, taxonomic (environmental, microbial, plants, invertebrate, and vertebrate), and …

Apple Podcasts or wherever you’re getting this and tell me why you’re listening. DAN: But, now, here’s Natural Prodcast … to try and create an open source database of all known microbial natural products. So if you think about natural … And that’s been followed by developments in pulse sequences and improvements in the ways in which you acquire …

… at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways … Canada. I just got back from a conference in Canada on antimicrobial resistance sponsored by the Garner foundation. And …

Joint Genome Institute is to serve the scientific community as a user facility pioneering functional genomics to solve … The ranked proposal list, along with a recommendation from management at JGI and the other participating … … For sequencing projects, once work is under way, raw sequence data is released to NCBI’s Sequence Read Archive on …

… tell us about this squid-microbe relationship. Or is it a microbial community with microbial community relationship?  … does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to …