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… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain …

… … DAN: You’re listening to the US Department of Energy Joint … then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against …

… … DAN: You’re listening to the US Department of Energy Joint … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… … DAN UDWARY: Hey, everyone! Welcome to the “Self Promotion … is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a …

…   The JGI’s Secondary Metabolites Program focuses on the exploration of secondary metabolites across bacteria, fungi, algae and … computational analyses of BGC size and complexity, BGC sequence composition, metabolic similarity & compatibility, …

The Metagenome Program uses advanced sequencing technologies to decode the genomes of microbes in their natural environments. This work … comprising the largest public collection of plasmid sequences identified from genomes, SAGs, MAGs, metagenomes …

… … DAN: You’re listening to the US. .Department of Energy Joint … at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways …

Machine learning methods were applied on sequenced fungal … genomes to classify gene families. The Science As a proof of concept, researchers developed an algorithm that …

… “Adopt a Genome” is an informal program for faculty to … work with undergraduates in the analysis and publication of the claimed genome sequences. This opportunity, provided by the Department of …

Every approved proposal starts with a User Agreement — before any work can begin, including the submission of samples for sequencing, or the submission of sequencing …

… … DAN: You’re listening to the US Department of Energy Joint … DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have …

Uncovering associations between plant roots and fungi that can help or … host health. The Science Researchers compared the genomes of fungi that colonize Arabidopsis thaliana roots with … from natural Arabidopsis populations around Europe. The JGI sequenced and annotated 41 fungal isolates from the …