Search

… And we’ve done some work with those and have a couple of publications out there on the chemistry. There’s so much … assays is what those would be. The work that we do at larger scale in order to look at the chemistry a little bit more … Natural Prodcast presents our interview with Professor Marcy Balunas , currently at the University of …

… and how we do it here and maybe give an example of a recent publication. ALISON TAKEMURA: Awesome. Yeah, let’s dive in, … regions of secondary metabolism should be. That’s still largely homology based, but then you’re using kind of a … might be everywhere, but only at a certain kind of coarse scale. DAN UDWARY: Yeah I think that’s right. That’s why I …

… try and understand, without any biases or dogma from the fields, like how microbes might produce antibiotics. So I … in those two fields and the ability to process samples at scale. So, lots of samples. ALISON: Yeah, how many samples … you for that insight. DAN: So I suppose, coming up with large collections of new microbes and new activities, feeds …

… DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast– a … be revisited. And I think that a secondary metabolism as a field, or subdisciplines, started to grow and have different … it’s a result of an evolutionary process that has led into large chemical diversity because the function relates to the …

… Secondary Metabolites Program focuses on the exploration of secondary metabolites across bacteria, fungi, algae and … in defense, nutrient acquisition and communication. Studying how these compounds are biosynthesized and their … crop enhancement. The program aims to tap into the largely unexplored biochemical diversity within secondary …

… of flavin monooxygenases, and more broadly about the field of biocatalysis and what needs to be done across … of them to be highly related to enzymes that we have been studying since day one in my lab that do oxidative … Sure. ALISON NARAYAN: And so we usually start on small scale in the lab. So we’ll run things in like little …

… .” This is kind of like a CSP, but you would be proposing a larger project that requires the work of two or more DOE … a new investigator who wants to try out something smaller scale, or if you’re just curious to know more, then I really … do the bioinformatics and to synthesize these results into publication? So there’s this really important because we …

… for researchers to request the capabilities and expertise of multiple DOE National User Facilities in one research … Successful applications will focus on high-risk/high-payoff proposals within the focused topic areas that can be … provides customized analysis, the JGI also participates in publication of results. …

… products, and we dive into the very early history of the field. If you continue on, in the next episode you’ll hear … secrete a lot more things than people do…? Although I don’t study people so maybe I’m wrong. But yeah, I mean, because I … derivatives of natural products.  ALISON: Like such a large diversity can have similar effects, I think is also …

… The JGI’s Metabolomics Program works to uncover the roles of small molecules in biological systems, linking them with genomic data to enhance our understanding of genome science, organisms, and ecosystems at the … processes, development of high performance plants and microbes, and understanding microbiome interactions. The  …

… in the early ’60s from Berkeley to work on this new budding field of marine natural products. And was at the university … that year that the Pacific Northwest had experienced the largest bloom ever observed on planet Earth. This was the … use our science to connect to problems that are on global scales. So I think that’s one area of science that we’re …