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… synthesizing activity based probes which are basically molecules that will covalently attach through a more … they can be things like biofilm formation. They can also be production, as we were mentioning before, of more complex … that shows potentially it’s regulated by one of these small molecules, how would you go about finding what that …

… bacterial, archaeal and eukaryotic microbes and viruses in environmental sequence data. We use multi-omics (metagenomics, metatranscriptomics, single cell genomics and phylogenomics) and machine learning to … Exploring the fascinating world of giant viruses, which challenge …

… Hey, Alison Takemura: Hey, Dan. Dan Udwary: Today we’re going to talk to Kate Duncan. And Kate is– I should ask, you … around countries. And I was actually in Croatia on a small island off the coast in the Adriatic Sea, and I … on ionizing, so you’re essentially getting only a subset of molecules that will fly on an analytical instrument and be …

… projects that address biological functions for biomanufacturing, critical minerals and materials, inter-organismal interactions, and … synthesis, metabolomics and analysis will be provided for free to the PI by the Department of Energy’s funding of the … For the CSP Large Scale call, a Letter of Intent (LOI) is required by the due date printed below. …

… actually are able to make some of these really interesting molecules, oftentimes much more efficiently than we can in … when I started doing a lot of this natural product production within bacteria, they're great at it, but it … So cis versus trans in order to cyclize at that small of a ring, which is highly unfavorable. DAN: Oh, I did …

… recognized and credited for their work, while also adhering to the authorship policies of the journal in which the research is published. The JGI expects that the … transparent and clear about our staff’s contributions. Feel free to reach out to your Project Manager or JGI Science …

… before we’re even thinking of genes and connecting genes to molecules, which is something that, you know, we take for … So we began to sequence that genome – it was a relatively small genome, about five and a half million base pairs. It … so we’ve done some work to try to do some elicitation of production and did some meta-T [meta-transcriptomics] on …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … always, because it could be something that’s, it could be a molecule that’s embedded in their – what do you call that – … yeah, so these guys, it turns out, produce lots of really small molecules that they use to communicate – lots of …

… at the end of the day, it’s because it is a hydrophobic molecule, flexible, that will confer one particular feature … They will allow promiscuity and the enzymes are driving the production of these compounds, which, in turn, translate … FRANCISCO BARONA-GOMEZ: Exactly. And I have just written a small piece where we discuss the future of merging …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … chains of amino acids. “Peptide” is just another word for a small protein. And it turns out that a lot of natural … interesting? And what we found is there are a lot of small molecules that are active, that are also found in the …

… tiny precursor peptide, encoding genes that encode the very small precursor peptides that end up being … clusters across different species, which all encode the production of either the same or similar molecules. And then of course, where you draw the boundary …

… DAN: You’re listening to the US. .Department of Energy Joint Genome … is focused on plants, but in both cases, you know, these molecules are how microbes communicate with the world around … cases. MARC: Yeah, and in some cases of really extremely small genomes, like symbionts that can’t live without their …