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Gene Expression: From On-Off Switch to Dial
… Scientists have developed a more nuanced library approach to tuning gene expression in metabolic pathways. Compared to the traditional way, which leverages an all-or-nothing … for other JGI users outside the realm of bioenergy optimization. Summary Life is all about balance. This …
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A Pinch of Salt Activates Silent Gene Clusters in Streptomyces
… efficiency for users requiring multiple omics methods to examine microbial chemical production. The Science Soil … the team mapped how the bacterium redirects its energy, building blocks and regulatory machinery toward chemical … the study provides a blueprint that engineers can use to design more efficient microbial factories. Identifying …
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A Better Way to Find RNA Virus Needles in the Proverbial Database Haystacks
… Team develops a computational pipeline to sift and characterize RNA virus sequences.  A zoo once … book featuring polar bears in winter scenes that came with crayons in various shades of white. To researchers … Advances in sequencing technologies and computational tools have uncovered a diversity of viruses that infect not …
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DOE Metrics
… FY 2026 DOE Metrics Sequencing Quarter Total Bases (Trillions) Operating Hours Goal  Actual Total*   Actual % of Goal   Goal (hours)**   Actual Total   … 50% reduced capacity for Q3 due to Clarity LIMS transition. **Includes Illumina HiSeq, Illumina NextSeq, …
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Finding the Fermenters
… prokaryotes. The Science Most organisms use oxygen to convert food into energy. However, in environments with little or no oxygen, life had found other ways to … Publication …
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Steven Wilson
… review, project and work order creation and management, automated sequence quality control and automation of … Wilson brings a user-centered approach, an ability to work with others to break down complex issues into achievable … he worked with the Informatics Department to develop software that pushed instrument run information directly …
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Leo Baumgart
… the DOE Joint Genome Institute in 2018, following his doctoral research in synthetic biology and microfluidics at the … operationalizing new genomic technologies, integrating automated liquid handling and bioinformatics pipelines to transition bench-scale methods into production workflows. He …
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A Complex Confection Decoded: Sugarcane Reference Genome
… Sugarcane was the last major crop without a reference quality genome and now crop researchers can work toward advancing sugarcane biotechnology. The Science Considered the world’s most harvested crop by tonnage, sugarcane accounts for 80% of global sugar … No. DE-AC02-05CH11231 with Lawrence Berkeley National Laboratory. The work conducted at CIRAD was supported by the …
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An Enzyme Family that Helped Shape Nitrogen Metabolism on Our Planet
… Researchers looked across many organisms to see that aminotransferase enzymes have evolved … National Laboratory (Berkeley Lab). He completed this work with collaborators at the University of Wisconsin-Madison as … this team built a phylogenetic tree using bioinformatic software called FastTree and identified 62 distinct AT …
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Litter chemistry influences decomposition through activity of specific microbial functional guilds
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JGI@25: Fueling Investigation into Methane-Making Microbes
… that showcase our collaborations and capabilities to enable great science that will help solve energy and … livestock — specifically, from the methane-making microbes within their rumen. There is another climate-minded reason … this study, researchers around the world are continuing to build on Hungate 1000 genomes and cultures to work toward a …
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Mining New Frontiers: The Critical Minerals and Materials Joint Call
… call . This represents a unique opportunity for researchers to request the capabilities and expertise of both national … Submit research proposals  here that integrate genomics with nanoscale science, accelerating discoveries and … Access to the Molecular Foundry and use of JGI capabilities is …
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