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Boosting Small Molecule Production in Super “Soup”
… from engineered yeasts still work in cell-free environments? (Spoiler: Yes.) Think of cells as tiny factories: … Program at the U.S. Department of Energy (DOE) Joint Genome Institute (JGI), a DOE Office of Science User … produced BDO at higher productivity rates than were noted inside the cell. “One of the huge advantages of the …
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How Filamentous Fungi Sense Food
… of California, Berkeley used a multi-omics approach to reconstruct and model gene regulatory pathways used by the … researchers at the U.S. Department of Energy (DOE) Joint Genome Institute (JGI), a DOE Office of Science User … proposal akin to the Encyclopedia of DNA Elements (ENCODE) project, which is aimed at determining the activity, …
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Gut Fungi: Unexpected Source of Novel Chemicals
… expensive feat thought to be too costly for them. The Science Anaerobic fungi, which die in the presence of … and help them digest their last leafy meal. In their evolutionary history, these fungi branched off early from aerobic … called natural products . Yet, combing through the genomes of four anaerobic fungal species has revealed, for …
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Webinar: Introducing the BioSANS capability
… for Structural Molecular Biology (CSMB) at Oak Ridge National Laboratory.   On March 2, 2021, the Environmental Molecular Sciences Laboratory hosted a webinar to showcase how … The U.S. Department of Energy Joint Genome Institute, a DOE Office of Science User Facility …
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Natural Prodcast Episode 23: Aaron Puri
… another episode of Natural Prodcast. Right now I’m working on this the afternoon of the day I’m due to release it, … in terms of their natural products chemistry, and he has a project with the JGI to synthesize the genes for and explore … And it actually was jumping onto the I ntegrated Microbial Genomes and Metagenomes, the IMG platform that JGI has that …
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JGI announces 2024 Functional Genomics awardees
… year, the JGI accepts proposals for state-of-the-art functional genomics research from reseachers who translate genomic … Through our CSP Functional Genomics call , we look for projects that will leverage the JGI’s DNA synthesis and omics capabilities to enhance understanding of gene and genome function. Tapping into these functions allows …
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A Natural Mechanism Can Turbocharge Viral Evolution
… Understanding how a fundamental mechanism of evolution allows microbes to adapt to changing environments. The Science The first step in the deadly dance between a virus … ago, a team discovered a group of viruses that had in their genomes a surprising tool: a “diversity generating …
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Boosting Small Molecule Production in Super “Soup”
… from engineered yeasts still work in cell-free environments? (Spoiler: Yes.) Yeast strains engineered for the … Program at the U.S. Department of Energy (DOE) Joint Genome Institute (JGI), a DOE Office of Science User … produced BDO at higher productivity rates than were noted inside the cell. “One of the huge advantages of the …
Learn more
Designer DNA: JGI Helps Users Blaze New Biosynthetic Pathways
… enabled by the JGI DNA Synthesis Science Program. Fashioning DNA outside a cell is key to interrogating what genes … This is where the U.S. Department of Energy (DOE) Joint Genome Institute (JGI), a DOE Office of Science User … in five years, have come out of the JGI-supported project. “The JGI DNA Synthesis Science Program has been …
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JGI announces 2025 Functional Genomics awardees
… Olufemi Isimikalu, Todd H. Oakley, BJ Philmus and Aaron M. Roshotte; [Below] Paul Scesa, Kathleen Scott, Tiffany … Through our  CSP Functional Genomics call , we look for projects that will leverage the JGI's DNA synthesis and omics capabilities to enhance understanding of gene and genome function. Tapping into these functions allows …
Learn more
Fungus Fuels Tree Growth
… Researchers start pinning down how a fungal symbiont spurs growth of poplar, a potential biofuel feedstock.     The Science The fungus  Mortierella elongata enjoys a dual … partnered with the U.S. Department of Energy (DOE) Joint Genome Institute (JGI), a DOE Office of Science User …
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Mapping Heat Resistance in Yeasts
… A new approach for improving functional annotation in fungal genomes. The Science In a … production. Efforts such as the 1000 Fungal Genomics Project led by the DOE Joint Genome Institute (JGI), a DOE … The work conducted by the US Department of Energy Joint Genome Institute, a DOE Office of Science User Facility, is …
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