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… work on human health or on medicines per se, how do you see genome mining and looking for secondary metabolites in … that’s a really good question. I think that’s something we sort of covered in the other primers. So people should go … machine learning really would help distinguish and predict novel gene clusters. DAN UDWARY: Yeah, it certainly could. …

DAN UDWARY: So I get all the podcast stats, right? And so I see all the download numbers. And so one of the things I’ve … products as an undergrad. So for me, it was studying sort of the interface of chemistry and biology because I was … seems to be a new structure, and the microorganisms are novel. I mean, we have Streptomyces , but they’re new …

… thinking about doing a postdoc and went to industry to see what they had, what data they had. DAN UDWARY: And they … And you can– we spot them by you can actually see consortia of microorganisms growing on the walls. They look … at this point. So no company would ever be interested in developing them, doing the substantial amount of effort to …

… program for faculty to “claim” the JGI’s unpublished microbial genomes, with the expectation that faculty will … of Energy Joint Genome Institute, builds upon thousands of microbial genomes that have been sequenced by the JGI though … up-to-speed with some of the latest developments in microbial genomics, metagenomics, and computational biology, …

… us about forthcoming efforts in paired-omics data sets and seeking to interpret function from BGCs. It’s a long, wide … time called Genbiotics , which was a large program to find novel antibiotics. And this particular project focused … So it sounds very– you guys are very open to outside input, sort of an open source model. Marnix Medema: Yeah, yeah. We …

Assembly, annotation ( IMG/M ), mapping 273/273 Metagenome Cell Enrichments Obtained by physical separation of a biologically relevant unit from a microbial community, such as a microcolony, microbial … ), methylation analysis 131/176 Microbial Single Particle Sort Draft quality assembly of amplified genomes from sorted …

… there– but look at these things in the ocean and see those medicines inside them. And this was, I think it … currently exist. We looked at chemistry, so it’s really novel. And they’re just really exciting. And it really kind … whole lot of mass spec– but I find it really interesting to sort of compare, conceptually, that data with genomics and …

… host-microbe chemistry.  We’re interested in – like I can sort of see when I’m doing the work or thinking about something I … bacteria into the jelly coat to protect the eggs as they’re developing over about a month.  DAN: What are those bacteria …

CASSANDRA QUAVE: OK, great. Well, hey, it’s so great to see both of you, Dan and Alison. And I strangely feel like I … use successfully, hopefully, in the future even more so as novel therapies. And that’s how I got on that path of … materials that you’re working on or the products you’re developing are being worked on or accessed under the …

… myself on my self-imposed schedule. So, we’ll have to see if I’m going to slip a day on releasing it into the … access the chemical potential of these or any organisms. So developing good heterologous expression hosts like maybe in … lot of sense to be spending a ton of energy producing some sort of– DAN: Especially as a system like a nonribosomal …

… the kinds of bacteria that, maybe, grow in one place and sort of stay there. And then, you know, they will have to … of plants. And these guys were sequenced, and you can see that different Frankia have different size genomes … often use primary metabolites as building blocks to produce novel molecules. And so we’ve got glycosides being made into …

… some of the technical challenges to that, most of which seem to be history.   I should mention that this is one of … could do to us. So I’d say my initial entry was more, sort of, in an agricultural sense in that both on what … you know, how are our crops and people – in particular in developing countries – being affected by parasites.   NANCY: …