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… that the data produced by the facility result in scientific publications. JGI users and collaborators have the right to produce manuscripts for publication and the responsibility for leading the … genomics data types as well as in advanced assembly and engineering strategies for DNA synthesis applications. If …

… mining company, back when DNA sequencing of natural product pathways was hard and expensive to do. As I said, Brian is … and he’s doing some amazing research in and around drug discovery, which includes screening methods, genome mining … with the synthetic biology community, with the metabolic engineering community because the skill sets are very …

… level. Integrating genomics with metabolomics fuels the discovery  of novel metabolites, genes, and proteins. It … biogeochemical processes, development of high performance plants and microbes, and understanding microbiome … including understanding enzymatic transformations, pathways, and how changes in metabolism can affect ecosystem …

… “Adopt a Genome” is an informal program for faculty to “claim” the JGI’s unpublished … faculty will work with undergraduates in the analysis and publication of the claimed genome sequences. This opportunity, provided …

… me really interested in microbial gene regulation and some pathways. And I thought I’d take an academic job then, but I … And so it was very much a co-Dow product.  DAN: Industrial discovery, yeah.  NIGEL MOUNCEY: Right. An amazing product, … help the Society grow. And so I’ve been the chair of the publications committee for the last, what is it now, five …

I really became more and more interested in cancer drug discovery and pharmacology but I didn’t know how to get … And we’ve done some work with those and have a couple of publications out there on the chemistry. There’s so much … And so then there isn’t horizontal transfer and so those pathways don’t have to be clustered so they end up probably …

… lab now is use these as a resource for natural product discovery because we can genetically manipulate them. I … where you start to do oxidation. DAN: There’s another pathway? That’s the one I remember from grad school. … up on previous Natural Prodcast episodes  here . Show Notes Publication: Suo Z et al. A Mesorhizobium japonicum quorum …

… program enables the design and synthesis of complex genetic pathways and biosystems. It The program fosters … to explore sequence-function relationships, advancing the discovery of new biosensors for biofuels and bioproducts. … enzymes to support mission-driven research. Rapid Metabolic Engineering: Metabolic engineering traditionally utilizes a …

… always been the main driver for secondary metabolism drug discovery. Because we always need new antibiotics. We need … and how we do it here and maybe give an example of a recent publication. ALISON TAKEMURA: Awesome. Yeah, let’s dive in, … cluster. And so we’ve learned a lot about how biosynthesis pathways happen, just by being able to find one kind of gene …

Sample and library preparation, DNA synthesis and pathway engineering Mass spectrometry based metabolomics Below is a … to completion of standard analysis.  Raw data is provided for all sequencing products below. In addition, JGI will …