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… UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast, a podcast about natural … and how we do it here and maybe give an example of a recent publication. ALISON TAKEMURA: Awesome. Yeah, let’s dive in, … it is that secondary metabolism is ancient and, therefore, widespread. So if secondary metabolism was there when– and …

… that the data produced by the facility result in scientific publications. JGI users and collaborators have the right to … acknowledgment (see Auspice Statement below) for the generation of sequence or metabolomic data, DNA synthesized, … assembly, analysis, annotation, verification, creation of genome browsers, etc. The users, collaborators, and JGI …

… products field as it relates to structure elucidation and genome mining, and how we might start to better connect … America brought to the UK? ROGER:  Yeah, it’s difficult to generalize, of course, but I felt overall that the British … – it’s really a bit of a mess. And many of the system wide tools that people would like to build would greatly …

… Udwary: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast, a podcast about natural … and BiG-SLiCE, and now the BiG-FAM database of biosynthetic gene cluster families. And he tells us about forthcoming … and seeking to interpret function from BGCs. It’s a long, wide ranging conversation and I’m so happy we got the chance …

… and he has a project with the JGI to synthesize the genes for and explore the chemistry of quorum sensing systems, specifically the acyl homoserine lactones.  If you listened … And it actually was jumping onto the I ntegrated Microbial Genomes and Metagenomes, the IMG platform that JGI has that …

… exposure to working with Streptomyces, learning more about genome mining, as well as isolation and a little bit of … oftentimes will bind to receptors within biosynthetic gene clusters. Specifically, these are Tet repressors that … not all coming from actinos. So that, we have a little bit wider spread since we're just doing bioinformatic searches. …

… UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast– a podcast about natural … the active site of an enzyme. So there is no promiscuity, generally speaking, in primary metabolism. Nevertheless, … are shaping each part of the metabolic network in each specific organism. Really, what matters is the forces that …

… in the early 2000s called Ecopia, which was a very early genome mining company, back when DNA sequencing of natural … really complex bioactive natural product molecules. It’s a wide ranging conversation, and we could have gone on for a … It was unpublished at that point. But people would push out gene clusters maybe once a month at most. Maybe twice a …

… The Metagenome Program uses advanced sequencing technologies to decode the genomes of microbes in their … along with their associated viruses and mobile genetic elements. Beyond exploring and characterizing … The Metagenome Program focuses on the high-throughput sequencing of …

… “Adopt a Genome” is an informal program for faculty to “claim” the … faculty will work with undergraduates in the analysis and publication of the claimed genome sequences. This … while nurturing a fresh cohort of users Reach the next generation of genome scientists and recruit new talent for …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a podcast about the … technology to help access complicated natural product gene clusters, and we’re all really excited about that, and … chance to deliver this molecule – very toxic molecule – to specific disease cells. So, the very first compound was …

… bit more into fungi and learning the differences of all the genetic differences and then expanded on on that knowledge … Breaking Bad, I guess. But no, you trained me in how to genome mine, so thank you for that. And you had to put up … And I think a lot of times, too, when we even look at publications, it’s always positive data, right? No one ever …