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The JGI has a strong interest in seeing that the data produced by the facility result in scientific publications. JGI users and collaborators have the right to … (see Auspice Statement below) for the generation of sequence or metabolomic data, DNA synthesized, and any …

The JGI’s Metabolomics Program works to uncover the roles of small molecules in biological systems, linking them with … level. Integrating genomics with metabolomics fuels the discovery  of novel metabolites, genes, and proteins. It … tools, the program supports foundational research related to soil nutrient cycling and health, terrestrial …

… “Adopt a Genome” is an informal program for faculty to “claim” the JGI’s … faculty will work with undergraduates in the analysis and publication of the claimed genome sequences. This opportunity, provided …

I really became more and more interested in cancer drug discovery and pharmacology but I didn’t know how to get … And we’ve done some work with those and have a couple of publications out there on the chemistry. There’s so much … genes in the organism in its sequence that encode for that biosynthesis. But sometimes you have to know what those are …

… always been the main driver for secondary metabolism drug discovery. Because we always need new antibiotics. We need … and how we do it here and maybe give an example of a recent publication. ALISON TAKEMURA: Awesome. Yeah, let’s dive in, … biosynthetic gene clusters, which are the genes that do the biosynthesis of a secondary metabolite, those are clustered …

… and he’s doing some amazing research in and around drug discovery, which includes screening methods, genome mining … research in Utah touches on many areas of natural products biosynthesis and drug discovery. If you enjoy the interview, … cells. We’ll find that. So it’s a generic– it’s a generic stress panel that we can now plug in. And it works on a …

… lab now is use these as a resource for natural product discovery because we can genetically manipulate them. I … the cell, right? AARON PURI: Yeah. So we can dive into the biosynthesis of these as much as you want but they– so … up on previous Natural Prodcast episodes  here . Show Notes Publication: Suo Z et al. A Mesorhizobium japonicum quorum …

… for you here today. We got the opportunity to talk to one of the real legends of natural products, Professor Bill … We also talk about his move to microbiology, about drug discovery and why it’s so hard to succeed, and we talk about … and exploring marine bacteria for novel chemistry. Related links: Bill’s early thoughts on marine bacteria. Fun …

Secondary Metabolites Program focuses on the exploration of secondary metabolites across bacteria, fungi, algae and … characterization, the program strives to facilitate the discovery of new bio-based molecules that can drive … Deciphering regulatory networks of secondary metabolite biosynthesis: We have developed Regulon Identification by in …

I did my Ph.D. with Craig Townsend and worked on aflatoxin biosynthesis, aflatoxin being a secondary metabolite from an … of even one fungus in a taxon, then you can sequence related fungi and have crappy – Well, you know, you can have … thing too. Microbes produce natural products in time of stress. A lot of these natural products, they’re protections …