MetaHipMer2 is being used to support a broad array of metagenomics-based user science at the JGI. Top: One of the datasets involves samples from Lake Mendota, a large freshwater lake in Wisconsin. Bottom: Time series graph with sample dates in the Lake Mendota archive. Filled symbols correspond to dates for which 16S rRNA gene tag data are already available. (Courtesy of the McMahon Lab)