Search

… is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a … seems to be a new structure, and the microorganisms are novel. I mean, we have Streptomyces , but they’re new …

When submitting sequences to the JGI DNA Synthesis program, please include the following items: … Sequence files for all constructs should be emailed to  … several easy-to-use open source tools for converting DNA sequence files into well-formed GenBank files. ApE is an …

… to kill cells. So it’s really remarkable in terms of a novel mechanism, how a small molecule can kill. So that … the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very …

… more than 50,000 genomes that we derived from meta-genome sequences. As always, you’ll find transcripts and show notes … for us– what organisms people use for genome mining, why it’s called genome mining, how the biosynthetic gene … machine learning really would help distinguish and predict novel gene clusters. DAN UDWARY: Yeah, it certainly could. …

Prodcast. And it’s our conversation with Nadine Ziemert from the University of Tübingen in Germany. Like me, she’s a … there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And I think … it would work, but we actually found fosmids. And we sequenced the whole fosmid at the time with Sanger …

… of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. … to identify what’s being made. In some cases it might be novel, in some cases it might be– might be a known structure …

… week, we have our conversation with Professor Eric Schmidt, from the University of Utah. I’ve known Eric for a long time … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … in order to put them together to build pathways, to make novel compounds, or to find analogs. And that was Warp …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … an exploration into the secondary metabolism of some more novel marine bacteria. You know, I first met Bill as a … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …

… (see Auspice Statement below) for the generation of sequence or metabolomic data, DNA synthesized, and any other … is done in a timely fashion. The publications resulting from such efforts should specify the collaborative nature of … annotation, comparative analysis, and interpretation of sequence, metabolomics, and functional genomics data types …

… capabilities and products . A minimum request of 1 Tb of sequence data is required to qualify for BERSS. For DNA … with grants funded by DOE-BER requiring support from the JGI may  submit proposals here . Investigators … from lignin left over after biomass processing. Great Lakes Bioenergy Research Center , led by the University of …