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… I got the chance to do genome mining on more than 50,000 genomes that we derived from meta-genome sequences. As … and do some really complicated carbon skeleton rearrangements, chemistry that we probably don’t [need to] get … machine learning really would help distinguish and predict novel gene clusters. DAN UDWARY: Yeah, it certainly could. …

… approaches to identify and characterize genomic information from uncultivated microbes and viruses. We develop … computational approaches to sift through thousands of metagenomes for signatures of viruses and novel microbial lineages, and reconstruct metabolic …

… with recent computational technology advances in management, processing and visualization of “big data,” and … 2014), unearthing hundreds of thousands of new viral genomes and their predicted hosts (Nature 2016, Science … of the functional dark matter as well as the development of novel methods to enable large-scale comparative analysis, …

… is focused on the discovery and characterization of novel bacterial, archaeal and eukaryotic microbes and … of Life. We then investigate the coding potential to find novel functions that may impact microbiome structure and … and complexity, and encode for a treasure trove full of novel genes ready to be tapped for downstream applications. …

… Program uses advanced sequencing technologies to decode the genomes of microbes in their natural environments. This work … drive innovations that could advance our understanding of Earth’s ecosystems. … catalog of viral, microbial, and microeukaryote genomes and mobile genetic elements, linked to custom …

… genomics with metabolomics fuels the discovery  of novel metabolites, genes, and proteins. It also enables … mass spectrometry-based methods to analyze metabolites from a wide range of biological and environmental samples — … imaging, and other data from EcoFAB systems can provide novel insights into the impact of microbial symbionts and …

… for faculty to “claim” the JGI’s unpublished microbial genomes, with the expectation that faculty will work with … Joint Genome Institute, builds upon thousands of microbial genomes that have been sequenced by the JGI though not … talent for biosciences.  Adopt-a-Genome has: ~20 faculty from institutions across the country Efforts in ongoing …

… While an ever-increasing number of phage and virus genomes have been assembled and reported from metagenomes, our understanding of the impacts of these … and ultimately predict the main viral impacts in these microbiomes. … the range of virus-host interactions occurring in microbiomes, these omics data must be complemented with …

… leads to identification of biosynthetic gene clusters for novel secondary metabolites for multiple applications. … methods in the past decade, researchers have uncovered genomes for just a small fraction of Earth’s microbial … November 9, 2020 in  Nature Biotechnology . Known as the GEM (Genomes from Earth’s Microbiomes) catalog, this work …

… solutions in energy, agriculture and ecosystem management. … solutions in agriculture, energy and ecosystem management. The program aims to generate high-quality genomic … in particular to study inter-organismal interactions. Novel approaches are being explored to predict microbial …

… you’ll be hearing about microbiology and natural products from the Great Salt Lake, and you’re going to learn, like … organisms we’re finding– at least by looking at their full genomes — are really not like anything that’s been … seems to be a new structure, and the microorganisms are novel. I mean, we have Streptomyces , but they’re new …

… is really another example. This sort of carbon arrangement, which we know as a structure of a natural product, … to kill cells. So it’s really remarkable in terms of a novel mechanism, how a small molecule can kill. So that … well. One is to do DNA sequencing. So upon sequencing many genomes, now we don’t have to, as in the past, go randomly …