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… just deposit and take off. And so they must be chemically protected in some way and lo and behold it’s this bacteria. … we also went back to the glaciers and had this custom drill made to drill about two feet of glacier core that we field … MARCY : It’s getting bacteria from there. We work on a fungus garden ant as well as the American honeybee. And so I …

… beyond what each of these facilities could generate by itself.   Accepted projects must address or be otherwise … no cost to the user and no granting of funds. All data is made publicly available in accordance with  JGI’s Data … technologies available at JGI and EMSL such as DNA-SIP, Protein SIP, Flux Balance analysis with metabolites, Isotope …

… ecology. I studied Vibrio species in the ocean, so heterotrophic bacteria. Now, we didn’t get into secondary … a picture in your head. It’s a warm summer day, it’s been dry for a while maybe it hasn’t rained in a while. Picture … susceptible to a fungal infection of rye grain – a specific fungus, Claviceps purpurea, can infect grain. And when it …

Cochliobulis heterostrophis . This is a very well known fungus because it produces a secondary metabolite or natural … asexual spore, some might be in these things we called sclerotia, which are overwintering bodies. So the complexity … to get anywhere. They’re too hard to work with.” And that made me more determined than ever to stick with fungi. And …

… plant pathogens to use in agriculture and animal husbandry. So we’re looking for those kinds of activities as well. … the lab of Cameron Currie. They work primarily within the “fungus growing ant” system where there is a symbiont, a microbe, that produces antibiotic chemistry to protect the crop that the ants grow. So it’s a cool …

… feel like Cassandra Quave has put herself on the page and made herself really knowable through her book. And it was … way. So I had to leave with that chance when it presented itself. ALISON TAKEMURA: So I have an idea of where we could … Diversity . And there’s something called the Nagoya Protocol on access and benefit sharing. And for a very long …

… on this: Most of the machinery in any living organism are proteins, which are made up of chains of amino acids. “Peptide” is just another … bacteria that live in animals and with animal metabolism itself, and it’s really amazing what diversity there is in …

They might have enough nutrients, but they might want to protect those nutrients with antibiotics. They might need to … metabolism, they are copies and changes that nature has made. So secondary metabolism is adaptation of primary … blob – sort of overexposed – but this this white blob is a fungus called Penicillium . Now called Penicillium . And so …

… of things. Full stretch all the way from a well into microtiter plate all the way up to supporting 200,000-liter … aspects of the strain, as well as the fermentation process itself. And we built a nice modeling feedback loop for the … community, but it was again another product, an organism made that was then further transformed.  DAN: Sure.  NIGEL …

DNA sequence – sequences for the genes that code for the proteins that produce secondary metabolites. Do you recognize … say you knew you had a molecule. And you knew that if you made this change, which might be a small change, might be a … using biological systems. You know, if we had had the fungus that was making the Taxol rather than the tree – if …

… of the molecules and then looking at how they were made was really interesting and intriguing to me. And I … yeah. And what? Because the lake is sort of consistently drying out, or it’s periodic at least? You get a lot of wind … are not publicly available because sometimes we want to protect the clusters we’re working on and not get scooped. …

Dan: Yeah. So when I talk to Brad, this is when I get made fun of. So yeah, this will be fun. All right. Brad: … on marine actinobacteria. Then we moved into marine proteobacteria. Not a big leap, but then we began looking at … which can have genomes larger than the seaweed itself. Then there’s obviously a little bacteria there too, …