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… that the data produced by the facility result in scientific publications. JGI users and collaborators have the right to … acknowledgment (see Auspice Statement below) for the generation of sequence or metabolomic data, DNA synthesized, … is done in a timely fashion. The publications resulting from such efforts should specify the collaborative nature of …

… mining company, back when DNA sequencing of natural product pathways was hard and expensive to do. As I said, Brian is … and he’s doing some amazing research in and around drug discovery, which includes screening methods, genome mining … It was unpublished at that point. But people would push out gene clusters maybe once a month at most. Maybe twice a …

… and he has a project with the JGI to synthesize the genes for and explore the chemistry of quorum sensing … lab now is use these as a resource for natural product discovery because we can genetically manipulate them. I … where you start to do oxidation. DAN: There’s another pathway? That’s the one I remember from grad school. …

… bit more into fungi and learning the differences of all the genetic differences and then expanded on on that knowledge … tools and how to really access and manipulate these pathways to get new compounds. And lots of– had some really … And I think a lot of times, too, when we even look at publications, it’s always positive data, right? No one ever …

… for fundamental growth, provide critical advantages to the organisms producing them, and are often involved in defense, … conditions, with only a small portion of the biosynthetic gene clusters (BGCs) being expressed. The program works to … these hidden biochemical resources by exploring the genetic pathways responsible for their synthesis. The Secondary …

… my undergraduate in microbiology and then PhD in microbial genetics in the UK. And came across to the US for a couple … me really interested in microbial gene regulation and some pathways. And I thought I’d take an academic job then, but I … help the Society grow. And so I’ve been the chair of the publications committee for the last, what is it now, five …

… data to enhance our understanding of genome science, organisms, and ecosystems at the molecular level. Integrating genomics with metabolomics fuels the discovery  of novel metabolites, genes, and proteins. It also enables exploration of energy … including understanding enzymatic transformations, pathways, and how changes in metabolism can affect ecosystem …

… ALISON TAKEMURA: I know that it’s looking in the genome for genetic elements of interest, you know, something like … and how we do it here and maybe give an example of a recent publication. ALISON TAKEMURA: Awesome. Yeah, let’s dive in, … cluster. And so we’ve learned a lot about how biosynthesis pathways happen, just by being able to find one kind of gene …

… of it. So it wasn’t only chemistry or only biochemistry or genetics. It was also ecology. It was also evolution. It was … There’s gene fusion going on, and then I could see how the pathway gets streamlined and becomes more effective. That’s … Usually, in a lot of cases, we still have to go through publications to get proteins, and their functions, and all …

… Prodcast. This week, Alison and I talk to Roger Linington, from Simon Fraser University in British Columbia, Canada. … Bill Gerwick as part of the International Biodiversity Drug Discovery consortium doing natural products … America brought to the UK? ROGER:  Yeah, it’s difficult to generalize, of course, but I felt overall that the British …

… And we’ve done some work with those and have a couple of publications out there on the chemistry. There’s so much … products is that we don’t know what all the biosynthetic gene clusters look like.  DAN: For sure.  MARCY: We have so … And so then there isn’t horizontal transfer and so those pathways don’t have to be clustered so they end up probably …

… it, but it has a really fun and interesting biosynthetic pathway, and I’ll have to do a whole show on it one of these … see as the overall “theme” of your research? I know you’ve generally worked in various marine organisms. Except during … in that. And we have a project working on pain drug discovery from those animals. A second area that I’m really …