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… that the data produced by the facility result in scientific publications. JGI users and collaborators have the right to … acknowledgment (see Auspice Statement below) for the generation of sequence or metabolomic data, DNA synthesized, … is done in a timely fashion. The publications resulting from such efforts should specify the collaborative nature of …

… mining company, back when DNA sequencing of natural product pathways was hard and expensive to do. As I said, Brian is … and he’s doing some amazing research in and around drug discovery, which includes screening methods, genome mining … It was unpublished at that point. But people would push out gene clusters maybe once a month at most. Maybe twice a …

… and he has a project with the JGI to synthesize the genes for and explore the chemistry of quorum sensing … where you start to do oxidation. DAN: There’s another pathway? That’s the one I remember from grad school. … up on previous Natural Prodcast episodes  here . Show Notes Publication: Suo Z et al. A Mesorhizobium japonicum quorum …

… bit more into fungi and learning the differences of all the genetic differences and then expanded on on that knowledge … tools and how to really access and manipulate these pathways to get new compounds. And lots of– had some really … And I think a lot of times, too, when we even look at publications, it’s always positive data, right? No one ever …

… conditions, with only a small portion of the biosynthetic gene clusters (BGCs) being expressed. The program works to … these hidden biochemical resources by exploring the genetic pathways responsible for their synthesis. The Secondary … characterization, the program strives to facilitate the discovery of new bio-based molecules that can drive …

… my undergraduate in microbiology and then PhD in microbial genetics in the UK. And came across to the US for a couple … me really interested in microbial gene regulation and some pathways. And I thought I’d take an academic job then, but I … help the Society grow. And so I’ve been the chair of the publications committee for the last, what is it now, five …

… level. Integrating genomics with metabolomics fuels the discovery  of novel metabolites, genes, and proteins. It also enables exploration of energy … including understanding enzymatic transformations, pathways, and how changes in metabolism can affect ecosystem …

ALISON TAKEMURA: I know that it’s looking in the genome for genetic elements of interest, you know, something like … and how we do it here and maybe give an example of a recent publication. ALISON TAKEMURA: Awesome. Yeah, let’s dive in, … cluster. And so we’ve learned a lot about how biosynthesis pathways happen, just by being able to find one kind of gene …

… of it. So it wasn’t only chemistry or only biochemistry or genetics. It was also ecology. It was also evolution. It was … There’s gene fusion going on, and then I could see how the pathway gets streamlined and becomes more effective. That’s … Usually, in a lot of cases, we still have to go through publications to get proteins, and their functions, and all …

… it, but it has a really fun and interesting biosynthetic pathway, and I’ll have to do a whole show on it one of these … see as the overall “theme” of your research? I know you’ve generally worked in various marine organisms. Except during … you’d like to read more about this, I highly recommend his publication last year, “The Biosynthetic Diversity of the …

Prodcast. This week, Alison and I talk to Roger Linington, from Simon Fraser University in British Columbia, Canada. … Bill Gerwick as part of the International Biodiversity Drug Discovery consortium doing natural products … America brought to the UK? ROGER:  Yeah, it’s difficult to generalize, of course, but I felt overall that the British …

And we’ve done some work with those and have a couple of publications out there on the chemistry. There’s so much … products is that we don’t know what all the biosynthetic gene clusters look like.  DAN: For sure.  MARCY: We have so … And so then there isn’t horizontal transfer and so those pathways don’t have to be clustered so they end up probably …