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… of secondary metabolism. Welcome back. This will be episode 12 of Natural Prodcast. And it’s our conversation with … Europe. So if there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And I think you’ll enjoy it. So here it is, episode 12 with Nadine Ziemert. DAN UDWARY: Hey, Alison. ALISON …

… that there was almost nothing. Now, this is back in the 1970s. So, I thought to myself, maybe I can use my … natural products in the ocean weren’t studied up until the 1970s. You know, I mean, people knew about plants’ chemistry … do research. And it moved me to ask a simple question. In 1929, Alexander Fleming discovered a molecule called …

… as well as a unique opportunity to complete a California K-12 science or math teaching credential as an undergraduate …

… within the realm of education. … Through the Berkeley Lab K-12 program, the JGI collaborates with Biotech Partners to …

… phages.  Current Opinion in Virology .  49 , 117-126 Berg, M. and Roux, S. (2021) Extreme dimensions — how … can tailed phages be?  Nature Reviews Microbiology.   19 , 407 Berg, M. et al. (2021) Host population diversity as … interactions. ISME J.   15 , 1569–1584 Roux, S. et al. (2019) Cryptic inoviruses revealed as pervasive in bacteria and …

Adopt-a-Genome has:  11 CSU educators working with the JGI 120 genomes claimed (or about one per student) Seven … et. al.  2023 . Microbiology Resource Announcements. 2023 12 (10), e00548-23 Whole genome sequence of the denitrifying …

… there a way to do that? DAN UDWARY: Well, so there’s good news and bad news on that. So one of the things that we’re trying to do … happening. And so we should have somewhere around 10, 11, 12 million BGCs in the database on the release, and that’s …

Right, because they’re so reactive. BEN: …going back to the 1950s. But the structure of which was not known until the … right? BEN: Yeah, yeah. Well, we are at [10 to the] minus 12 [Molar concentration]- is sufficient to kill cells. So … So I wanted to ask you also about – because you were in the news recently – TSRI has acquired the Pfizer strain …

… access to the whole sigma catalog of precursors in their 12C form. You can feed those and look for incorporation in … would grow up our bacteria on 13C methane or methanol, feed 12C methionine, and we were able to pull out the quorum … source and the other with 13C carbon source plus your 12C precursor. You look for a shift of four. Boom. It works …

… 10 to the negative 9th. Picomolar, 10 to the negative 12th. DAN: Yeah. So very-- BETSY PARKINSON: Very, very-- … the issues is in order to make the tetrapeptide, that's a 12 membered ring. And there's extreme ring strain in 12 membered rings. You also have to change the amide …