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… DAN: Hello, everyone, and Welcome back for Episode 14 of Natural Prodcast . There’s been a lot going on, so I … never forced it on me, but we always had these scientific news magazines lying around at home. And I would just pick … takes about 10 years. Costs are in the range of $100 to $120 million to do that.  DAN: OK. So about the same amount …

… of secondary metabolism. Welcome back. This will be episode 12 of Natural Prodcast. And it’s our conversation with Nadine … Europe. So if there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And … in the field, and I’m looking forward to trying out ARTS 2.0, which was published shortly after we talked. …

… materials. The proposal submission deadline is March 31, 2026 .  … (CMMs). Click for a list of CMMs and the results of the 2023 DOE Critical Materials Assessment . While we expect most … the Molecular Foundry, the project needs to be scoped for 12 months or less. We can help you scope that part of the …

… as well as a unique opportunity to complete a California K-12 science or math teaching credential as an undergraduate …

… the global diversity of alternative genetic codes (Science 2014), unearthing hundreds of thousands of new viral genomes and their predicted hosts (Nature 2016, Science 2017, Nature Microbiology 2018), discovery of … Reveal Thousands of Small, Novel Genes. Cell 178(5):1245-1259 Nayfach S, et al, (2019) New insights from …

… was like a nice summer day in Seattle I think this was like 2013 or 2014. And antiSMASH — I know you’ve interviewed Marnix … access to the whole sigma catalog of precursors in their 12C form. You can feed those and look for incorporation in … lactone signal . mBio. 2023 Aug 31;14(4):e0101023. doi: 10.1128/mbio.01010-23. Publication: Cummings DA Jr. Methylotroph …

… Cas14 proteins discovered from JGI’s IMG/M database and … acids (aa) in size, half that of previously known class 2 CRISPR enzymes that are typically 950—1400 aa. They were initially identified by searching for Cas12d homologs across IMG/M’s assembled metagenomic data. It …

… in this hypersaline environment, which can range from 8% to 28% salinity. We have toxic metals, so these concentrations … there a way to do that? DAN UDWARY: Well, so there’s good news and bad news on that. So one of the things that we’re … happening. And so we should have somewhere around 10, 11, 12 million BGCs in the database on the release, and that’s …

… right? BEN: Yeah, yeah. Well, we are at [10 to the] minus 12 [Molar concentration]- is sufficient to kill cells. So … So I wanted to ask you also about – because you were in the news recently – TSRI has acquired the Pfizer strain … look at several natural product enediyne structures, Ben’s 2015 paper on genome mining for enediynes is one of my …

… found in Yu et al, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2004, 1253–1262, 70:3 ALISON TAKEMURA: And so did you succeed in … Microbiomes” paper is here . Read the associated JGI news release here . Software we discussed, used for genome … reviews of genome mining: Ziemert, Alanjary, and Weber’s 2016 overview of genome mining (open access) The …

… list available at Google Scholar. Dutkiewicz, Z. et al (2025) “ Proposal of Patescibacterium danicum gen. nov., sp. … ISME Communications , Volume 5 Issue 1. Wittmers, F. et al (2024) “ Non-photosynthetic lineages sibling to Cyanobacteria …