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… went on to work at a groundbreaking company in the early 2000s called Ecopia, which was a very early genome mining … And I thought, well, I know that we can do this. So in 2006 was when I started our cave-based natural product … of thing. But it’s a lot of work. So to me, to us, about 6 years ago, we thought the big gap in genome mining is not …

Adopt-a-Genome has:  11 CSU educators working with the JGI 120 genomes claimed (or about one per student) Seven … Xenorhabdus cabanillasii DSM17905, Xenorhabdus ehlersii DSM16337, Xenorhabdus japonica DSM16522 R Robertson, et. al.  … DSM 14810 (JK 615T) and  Butyrivibrio fibrisolvens DSM 3071 (D1T).  K Berner, et. al.  2024.  Microbiology Resource …

… available at Google Scholar. Schulz, C Abergel, T Woyke (2022) Giant virus biology and diversity in the era of … metagenomics. Nature Reviews Microbiology volume 20, 721–736 JC Villada, F Schulz (2022) The endosymbiotic box of … through global metagenomics. Nature. 578 (7795), 432-436 Schulz et al. (2020) Advantages and limits of metagenomic …

… found in Yu et al, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2004, 1253–1262, 70:3 ALISON TAKEMURA: And so did you succeed in finding … Microbiomes” paper is here . Read the associated JGI news release here . Software we discussed, used for genome …

Myco-Ed has:  ~50 lineages selected for sequencing 16 genomes released 20 members from 15 institutions 300+ students 800+ …

Europe. So if there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And … ALISON TAKEMURA: And this is Paul Jensen in the early 2000s? Late 2000s? NADINE ZIEMERT: No, yeah, 2010. ALISON … all these very, very related genomes, right – on their 16S level, they’re almost identical! But seeing all these …

… never forced it on me, but we always had these scientific news magazines lying around at home. And I would just pick … screening platform where we’d look at 10,000, 15,000, 20,000 mutants a week. We started doing a whole bunch of … looking at emails and I just saw this pop up. And saw a C&E News job little box and I thought, wow, this would be …

… company Wyeth that introduced enediynes to the market in 2001 with a drug called Mylotag. Wyeth was later acquired by … So I wanted to ask you also about – because you were in the news recently – TSRI has acquired the Pfizer strain … these natural products. So this gives you approximately a 6% successful drug discovery rate.   And this is 100 times …

… reminds me almost working with Bill back in the ’50s and ’60s of the golden age of antibiotic discoveries. Everything … WINTER: Wow. DAN UDWARY: And I think we’ve got another 200,000 or 300,000 bacteria to go in before we go to the 1.0 … there a way to do that? DAN UDWARY: Well, so there’s good news and bad news on that. So one of the things that we’re …

… seems hard to believe in retrospect. BILL FENICAL: Well, in 2021, absolutely hard to believe. But when you go way back, … with the National Cancer Institute who had a panel of 60 different cancer cell lines. And we would send them these … using modern phylogenetic tools measuring genes, the 16S gene, and comparing it with everything that’s known. So …