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… One of the JGI’s key assets is our user community, comprising a broad range of researchers and trainees who use JGI resources and …

… Researchers looked across many organisms to see that aminotransferase enzymes have evolved mix-and-match characteristics — … this gap, by tracing the evolution of a specific enzyme family called aminotransferases (ATs). These enzymes play a …

… DAN UDWARY: You’re listening to the Department of Energy … for you. A lot of this is based on a really great paper that came out in 2020 where this is all explained in detail, … will be very flexible. They will allow promiscuity and the enzymes are driving the production of these compounds, …

… DAN UDWARY: Hey everyone. Welcome back to Natural Prodcast. … as exploring and exploiting biocatalysts – that is, using enzymes to do chemical reactions. Obviously, in my work, in … in a route towards many different compounds in the same family. And so that you want it to have some promiscuity in …

… DAN: You’re listening to the US Department of Energy Joint … pathways. Not every organism, at least, has something that’s maybe obvious or notable. We are still in – not an … I think is also really interesting. Because glycosides are shaped so differently from polyketides. At least I mean, I …

… Our research is focused on the discovery and characterization of novel bacterial, … investigate the coding potential to find novel functions that may impact microbiome structure and biogeochemical … Exploring the fascinating world of giant viruses, which challenge our understanding of viral …

… With collaborative user projects, the JGI’s Plant Program delves into the natural world’s potential to … challenges by exploring plants’ role in capturing carbon, detoxifying soils, interacting with other organisms, and … interactions, advancing efforts to create renewable energy sources and bolster agricultural resilience. The program’s …

… DAN: You’re listening to the US Department of Energy Joint … darn cool to have that legacy and that running in your family. Dan: So tell me about that. What sparked it? I mean, … might make this molecule and predicting what kind of enzymes might be involved, and then being able to make those …

… Dan Udwary: You’re listening to the Department of Energy … some of these enormous genes that encode these very large enzymes. And I was like, OK, wow, these are really cool. And … nicer than MIBiGC or MIBIC. Dan Udwary: Yeah. And the big family continues. So next I think was BiG-SCAPE and now …

… As a National User Facility, the JGI serves more than 2,500 users that predominately come from the public sector: academic and … review. The process is streamlined, with defined deadlines and straightforward submission steps.  … SPPs enable research funded by an industry partner to perform a defined scope of work using …

… DAN UDWARY: You’re listening to the Department of Energy … there was a biosynthetic gene cluster there. But that’s one family of biosynthetic genes. And so, I think antiSMASH– oh, … ago. Non-ribosomal peptides, remember, are big, complicated enzyme systems that really just exist to pull an amino acid …

… DAN: Hello, everyone, and Welcome back for Episode 14 of … Gluconibacter .  And that got me back a little bit to redox enzymes and looking at gene regulation. And then from there, … of about 75 people. So our biggest project was the spinosyn family of insecticides that Dow had already commercialized …