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… of secondary metabolism. Welcome back. This will be episode 12 of Natural Prodcast. And it’s our conversation with … Europe. So if there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And …

… metabolism. Hey everybody, this is Dan with episode 13 of National Prodcast. This continues our little section … of this is based on a really great paper that came out in 2020 where this is all explained in detail, so if you’d like … and I hope you’ll enjoy it too. So here we go– episode 13 with Paco Barona-Goméz. DAN UDWARY: Hey Alison. ALISON …

… went on to work at a groundbreaking company in the early 2000s called Ecopia, which was a very early genome mining … and against primary cells isolated from patients up to 12 markers at a time. And these are phenotypic markers. So … at Scripps, I guess, 22 years ago. And it’s over 130 steps to make everninomicin. DAN UDWARY: Yeah, one of …

… recruit new talent for biosciences.  Adopt-a-Genome has: ~20 faculty from institutions across the country Efforts in … development and adoption of classroom modules Currently 206 genomes have been selected with 11 published manuscripts … Resour Announc 0:e00891-25. https://doi.org/10.1128/mra.00891-25 . B. Christenson, I. Nouioui, C. Daum, M. …

… was like a nice summer day in Seattle I think this was like 2013 or 2014. And antiSMASH — I know you’ve interviewed Marnix … access to the whole sigma catalog of precursors in their 12C form. You can feed those and look for incorporation in … Stable Isotopic Labeling . ACS Chem Biol. 2021 Aug 20;16(8):1332-1338. doi: 10.1021/acschembio.1c00329. …

… materials. The proposal submission deadline is March 31, 2026 .  … (CMMs). Click for a list of CMMs and the results of the 2023 DOE Critical Materials Assessment . While we expect … the Molecular Foundry, the project needs to be scoped for 12 months or less. We can help you scope that part of the …

… found in Yu et al, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2004, 1253–1262, 70:3 ALISON TAKEMURA: And so did you succeed in … Microbiomes” paper is here . Read the associated JGI news release here . Software we discussed, used for genome …

… there a way to do that? DAN UDWARY: Well, so there’s good news and bad news on that. So one of the things that we’re … happening. And so we should have somewhere around 10, 11, 12 million BGCs in the database on the release, and that’s … Metabolites Collaboratory SMC Workshop Materials from the 2023 JGI Annual Meeting Using the SMC Website API Endpoints …

… right? BEN: Yeah, yeah. Well, we are at [10 to the] minus 12 [Molar concentration]- is sufficient to kill cells. So … So I wanted to ask you also about – because you were in the news recently – TSRI has acquired the Pfizer strain … look at several natural product enediyne structures, Ben’s 2015 paper on genome mining for enediynes is one of my …

… list available at Google Scholar. Dutkiewicz, Z. et al (2025) “ Proposal of Patescibacterium danicum gen. nov., sp. … ISME Communications , Volume 5 Issue 1. Wittmers, F. et al (2024) “ Non-photosynthetic lineages sibling to Cyanobacteria … Issue 22. Krinos, A.I., Mars Brisbin, M., Hu, S.K. et al. (2024) “ Missing microbial eukaryotes and misleading …

… never forced it on me, but we always had these scientific news magazines lying around at home. And I would just pick … takes about 10 years. Costs are in the range of $100 to $120 million to do that.  DAN: OK. So about the same amount … Metabolites Science Program . Since his arrival in 2017, Nigel has led a vision for the JGI that sees secondary …