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… DAN: Hello, everyone, and Welcome back for Episode 14 of Natural Prodcast . There’s been a lot going on, so I … never forced it on me, but we always had these scientific news magazines lying around at home. And I would just pick …

… welcome back to Natural Prodcast, and this will be episode 11. This continues our little sprint on genome mining. In … talk and that now I can bring it to you. So enjoy, episode 11 of Natural Prodcast. Alison Takemura: Marnix, where are … a quick story. Looking back, the year was probably 2010, 2011, I was a, uh- actually, I’ve got the t-shirt on today. …

… there a way to do that? DAN UDWARY: Well, so there’s good news and bad news on that. So one of the things that we’re … happening. And so we should have somewhere around 10, 11, 12 million BGCs in the database on the release, and …

… this is Challis et al, Chemistry and Biology, 2000, 211-224, 7:3 And so, you can then make predictions about … Nature  Biotechnology . 2020 Nov 9. doi: 10.1038/s41587-020-0718-6) DAN UDWARY: Yeah, I think that might be a good … Microbiomes” paper is here . Read the associated JGI news release here . Software we discussed, used for genome …

… microbiomes. mSystems0:e01744-24. https://doi.org/10.1128/msystems.01744-24 Oliver, T., Varghese, N., Roux, S. et … metagenomic time-series from Lake Mendota. Sci Data 11 , 966 (2024). https://doi.org/10.1038/s41597-024-03826-8 … 39 , 499–509 (2021). https://doi.org/10.1038/s41587-020-0718-6 I-Min A Chen, Ken Chu, Krishnaveni Palaniappan, Anna …

… global diversity of alternative genetic codes (Science 2014), unearthing hundreds of thousands of new viral genomes … the human gut microbiome. Nature Biotechnol.  39(1):105-114. Schulz F, et al. (2020) Giant virus diversity and host … of metagenomics software. Nature Methods  14(11):1063-1071 Bowers RM, et al. (2017) Minimum information about a …

… from metagenomes. mSystems 9:e00888-24. https://doi.org/10.1128/msystems.00888-24 Coclet, C., Sorensen, P.O., Karaoz, … of hypermutation in the global microbiome. Nat Commun 12, 3076. https://doi.org/10.1038/s41467-021-23402-7 Roux, S. and Emerson, J. (2022) Diversity …

… modules Currently 206 genomes have been selected with 11 published manuscripts published to-date Testimonials: … Resour Announc 0:e00891-25. https://doi.org/10.1128/mra.00891-25 . B. Christenson, I. Nouioui, C. Daum, M. … DSM 14810 (JK 615T) and Butyrivibrio fibrisolvens DSM 3071 (D1T). Microbiol Resour Announc. 2024 0:e00517-24. …

… Cas14 proteins discovered from JGI’s IMG/M database and … report the identification of active Cas enzymes – dubbed Cas14 – that target ssDNA. In contrast, the seminal Cas9 … while Burstein is now at Tel Aviv University. The Cas14 proteins are ~400–700 amino acids (aa) in size, half that …

… So I wanted to ask you also about – because you were in the news recently – TSRI has acquired the Pfizer strain …