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Extracting the Secrets of Secondary Metabolites
… biosynthetic gene clusters.  The Science Microbial secondary metabolites, those molecules not essential for growth … Repeats) is the leading tool for accurately editing genomes, its effectiveness has historically been limited due … exactly how P. luminescens and its secondary metabolites work could yield new tools for pest control. Secondary …
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Gut Fungi: Unexpected Source of Novel Chemicals
… and help them digest their last leafy meal. In their evolutionary history, these fungi branched off early from aerobic … called natural products . Yet, combing through the genomes of four anaerobic fungal species has revealed, for … and commodity chemicals, as well as drop-in biofuels. This work shows that anaerobic fungi might be a new source of …
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Building Wet and Dry Lab Skills
… Summer 2025 marked the second year of Alabama A&M University students coming to the DOE Joint Genome Institute for research and training experience funded … project, undergraduate interns Tamyra Long and Zyiah Mikes worked with mentors Yi Zhai and John Vogel from the Plant …
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Identifying the Microbial Cleanup Crew at a Superfund Site
… reveals the microbial community involved in a bioremediation effort. The Science In 1999, the Environmental Protection … mccartyi and  Dehalobacter restrictus,  that work together to break down PCE into the chemical compound ethene. Applying genome sequencing and analysis, the researchers identified …
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Plotting a Model for Virus-Host Warfare Deep Below Ground
…   Visualizing a novel, candidate viral genome found in the deep subsurface ecosystem. The Science Altiarchaea are carbon-fixing microbes and targets of multiple viruses in … was  recently reported in Nature Communications. The work was co-led by Victoria Turzynski in Alexander Probst’s …
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DAP-seq Drives Robust Mapping of Gene Regulation
… assays yield an unprecedented view of plant evolution and adaptation.    Understanding how genes are regulated … life’s processes.  Traditionally, mapping this intricate network of regulatory “switches” in plants at a large scale was … to technical limitations and the sheer complexity of plant genomes. Now, with improvements to DNA Affinity Purification …
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Inaugural Critical Minerals & Materials Joint Research Portfolio Announced
… Sun, Olena Vatamaniuk, Setsuko Wakao, Meng Wang, and Allison Werner.   A total of 20 proposals were selected by the Joint Genome Institute (JGI) and the Molecular Foundry (TMF) for … environment. Users and members of their research teams work onsite at TMF alongside facility experts to conduct …
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An Inside Look at How Plants and Mycorrhizal Fungi Cooperate
… benefits to address climate change: pulling atmospheric carbon into soil and boosting biofuel feedstocks with less … organisms share space at cellular scale: fungi stretch a network of tendrils called arbuscules into a plant’s root … scientist at the U.S. Department of Energy (DOE) Joint Genome Institute (JGI), a DOE Office of Science User …
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Researching and Solving Real-World Problems with the 2023 JGI-UC Merced Interns
… For the first time in several years, the DOE Joint Genome Institute hosted several UC Merced students this past … Program was brimming with excitement and determination as they came onsite. From data carpentry to science … on Fungal Genomes Video Transcript: Emerald Nash : What I’m working on here is an experimental study of root …
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A Better Way to Find RNA Virus Needles in the Proverbial Database Haystacks
… Team develops a computational pipeline to sift and characterize RNA virus sequences.  … for sequences of RNA viruses in large data sets, their work may be akin to finding a single snowflake on a … Information, and the U.S. Department of Energy (DOE) Joint Genome Institute (JGI), a DOE Office of Science User …
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Tracing the Evolution of Shiitake Mushrooms
… New genomes highlight the diversity of white rot fungi in the … genus Lentinula, which have evolved to decompose hardwoods on every continent besides Europe and Antarctica. A  new … and assembling genomes from 60 existing sequences, this work expands the family tree for Lentinula. Within those …
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Dissecting the dominant hot spring microbial populations based on community-wide sampling at single-cell genomic resolution
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