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… want to go back and listen to the first two parts ( part 1 is here and part 2 is here ) so you understand what’s … episode 3 of the Primer! — DAN: So, you know, in the in the 50s 60s 70s, most of the exploration of this is done by … me to check her stat and she was absolutely correct. Since 2010 there have been eight new antibiotics added to the …

… cutting-edge.   … A record number of primary users — 2,475 — had active proposals with us, along with more than 15,000 secondary users who made use of our data. We … cell- and cell-free expression platforms.  … We closed our 2018 Strategic Plan at the end of September, 2023 with over …

… welcome back to Natural Prodcast, and this will be episode 11. This continues our little sprint on genome mining. In … to tell a quick story. Looking back, the year was probably 2010, 2011, I was a, uh- actually, I’ve got the t-shirt on … that you do, then it’s very easy to think that, OK, I find 25 gene clusters, there must be 25 new compounds. Or …

… because I was always swimming or surfing. And you know, 25 hours a day we’re at the beach practically. It was just – … pairs. It was not linear, like Streptomyces , but circular. 10% of the genome encoded natural product pathways. Dan: … has been a lot of fun for us in recent years. Started in 2015, when two things happened. One, a new graduate student …

… just did a low-resolution shotgun pass where we sequenced 500 runs. And then we used those to find gene clusters in … And I set that up. And we finally got that to work 10 years later. But in the meantime there, we had people … be difficult to write a grant on right now like another P450 or glycosyltransferase. You probably would have a hard …

… like a nice summer day in Seattle I think this was like 2013 or 2014. And antiSMASH — I know you’ve interviewed Marnix …

… who was working on these things in the very early 1900s.  DAN: And so he has drawn what he called … molecules and their discoveries over a stretch from 1940 to 2000. As you can see, from the 1940s, into the 50s into the 60s, there was a huge growth – a huge explosion …