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A Community Resource for Secondary Metabolite Researchers
… user engagement. The Science In addition to the core set of "primary metabolites"—chemical compounds shared by most … more than 13 million BGCs in the catalog at the time of publication, it is the largest repository of BGC sequence … and secondary metabolites information from isolate and metagenome data.   The SMC ( smc.jgi.doe.gov ) is designed …
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Sterol methyltransferases in uncultured bacteria complicate eukaryotic biomarker interpretations
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Toward More Reproducible, Reusable Stable Isotope Probing Experiments
… communities than ever before — especially with the prospect of meta-analyses boosted by AI and Machine Learning — JGI … from this group, as well as feedback from researchers around the world, the team have now published a  Minimum … easier to compare?” said Malmstrom, who worked with JGI Metagenome Program head Emiley Eloe-Fadrosh to host …
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Cataloging the Microbes that Manage the Health of River Systems
Database provides details on river microbes in 90% of US continental watersheds. The Science In a recent Nature … heading out to bays and oceans. While river microbes are critical to monitoring and maintaining the health of these … Northwest National Laboratory. The JGI sequenced over 1,000 metagenomes and established standardized sequencing …
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How to Target a Microbial Needle within a Community Haystack
A workflow for capturing the genetic make-up of specific uncultivated microbes from complex environmental … allow researchers to focus on specific microbes within metagenome samples and associate their sequences with their … probes, so the signal amplification provided by HCR-FISH is critical for detection. Once cells are labeled with …
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Evolutionary constraint facilitates interpretation of genetic variation in resequenced human genomes
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Accelerating Metagenomics Discoveries with Deep Learning
… insights from metagenomic data. In deep learning, a branch of machine learning, data is passed through algorithms … into multiple interconnected layers. The architecture of these algorithms, inspired by communication networks … that enable systems-based scientific approaches to these challenges.  DOE’s Office of Science is the largest …
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High-Throughput Translational Medicine: Challenges and Solutions
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CSP Large Scale Call
… on genomic science projects that address sustainable biofuel and bioproducts production, leveraging systems-based approaches to unravel functional capabilities of plants, microbes and microbial communities, global carbon … and nutrient cycling, and biogeochemistry — questions of relevance to DOE’s Office of Biological and Environmental …
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User Executive Committee Charter
… users and their science including technical capabilities offered, proposal review procedures, and the annual user … recommendations to the JGI regarding technical capabilities offered, including areas where more or less capacity is … annual JGI User Meeting, as well as input on other aspects of the meeting such as duration, location, and cost; …
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Metagenomics
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Vision, challenges and opportunities for a Plant Cell Atlas
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