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New Lineages of Life Group
… use multi-omics (metagenomics, metatranscriptomics, single cell genomics and phylogenomics) and machine learning to … possess genomes and particle sizes that rival those of cellular organisms. Giant viruses challenge the traditional boundaries between viruses and cellular life, providing unique insights into viral …
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Meta-virus resource (MetaVR): expanding the frontiers of viral diversity with 24 million uncultivated virus genomes
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JGI@25: Expanding Metagenomics to Capture Viral Diversity
… aspect of viruses in the environment — their sheer genetic diversity. As pioneers of this field, the JGI has leveraged metagenomics to … and grades their quality based on completeness. Along with expanding the viral diversity that IMG/VR features, teams at …
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JGI@25: A Single Cell, Myriad Microbial Discoveries
… quantities of DNA derived from individual environmental cells. The proof of principle study built off earlier … a way for researchers to study the planet’s microbial diversity, much of which remains unknown and uncultured in … a team studying microbial populations in oxygen minimum zones identified SAR11 bacteria as initiators of nitrogen …
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Metabolic potential of a single cell belonging to one of the most abundant lineages in freshwater bacterioplankton
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Igor Grigoriev
… the pharmaceutical industry. He holds joint appointments as Fungal and Algal Program Head at the JGI, a Senior Scientist … from protists to plants. In 2009, he launched the JGI Fungal Genomics program which resulted in over 2500 fungal genomes in the JGI MycoCosm portal. In 2018, he …
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DOE Metrics
… % Goal   FY 2026 Total   700.0     8,760     Q1 2026 175 313.081 179% 2,208 2,064 95.4% Q2 2026 175 243.806 139% … , which includes Principal Investigators (PIs), Co-PIs, and collaborators. *Unique users are counted once, even though … or plant genomes. [Download PDF] End-of-year Goal – Develop one new computationally enabled approach to analyze complex …
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Expanding Virophage Diversity
… with double-stranded DNA genomes that co-infect eukaryotic cells along with giant viruses. Virophages are small viruses … 10.9-42.3 Kb. Additionally, the gene counts have similarly gone up from 13-25 to 12-39. “Overall,” the team concluded, “we provide a global analysis of the diversity, distribution, and evolution of virophages.” Lead …
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Metabolomics Program
… while being simultaneously imaged and sampled.  Combining collected metabolomics data with genomics, transcriptomics, …
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Viruses Reprogram Cells into Different Virocells
… Microbial cells infected by viruses undergo metabolic reprogramming. … by a virus so that it no longer looks or quacks like one, is it still a duck? For a team led by researchers from … As part of efforts to characterize global microbial diversity with an aim to improve predictive ecosystems …
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Evolution of a Fungal Gene Expression Regulator
… on the largest analysis of 5mC distribution across the fungal tree of life to date, involving more than 500 species … development. Summary With the aim of producing at least one reference genome for every family of fungi, the 1000 … User Facility, and others like it, are uncovering the true diversity of the fungal kingdom. The abundance of fungal …
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The Expanding Universe of Methane Metabolisms in Archaea
… climate for life to flourish. For Guillaume Borrel and Simonetta Gribaldo of the Institut Pasteur in France, the … in nearly all types of anaerobic environments suggest the diversity of methane metabolisms is “vastly underestimated.” … carbon dioxide and hydrogen. Inskeep, a longtime JGI collaborator at Montana State University, commented that …
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