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… a bad location for a little baby. Rooming in, is what they call it, right? Alison Takemura: Yeah. Crashing. Maybe it’s … of hooks into IMG’s data. IMG being Integrated Microbial Genomics at JGI, a large data set of bacterial genomes. And … And I think another key component is data integration with genomics with metabolomics and with transcriptomics because …

… previous fiscal years for our Community Science Program (CSP) as well as the Facilities Integrating Collaborations …

…   Each year, the JGI accepts proposals for state-of-the-art functional genomics research from reseachers who translate genomic information into biological function. Through our CSP Functional Genomics call , we look for projects that …

DAN: Excellent, Yeah. OK, cool. So then what specifically about natural products? What got you in that … it’s really about what are they doing. And so it’s really functional genomics. And there’s a lot of sequencing based approaches, …

… are influenced by microbial partners. We use a variety of genomics-powered tools to study this complexity, including … barcode-based genetics (RB-TnSeq), and computational genomics to better understand the plant-associated …

… talking with a lot of people who actually have been classically trained in synthetic chemistry as were you and then … interesting. ALISON NARAYAN: It is a result that has a functional benefit for us, being chemists working with … that in and make that a solid retrosynthetic design. Also functionally, the supply of enzymes. Right? DAN UDWARY: …

… each year, the JGI accepts proposals for state-of-the-art functional genomics research from potential users who need help … genomic information into biological function. Through our CSP Functional Genomics call , we look for projects that …

… that might need special technology for DNA sequencing, genomics, metabolomics, and synthetic biology, that maybe … compounds that you find in plants, fungi and bacteria, basically all living things. When your crazy Aunt is posting on … at Scripps Institution of Oceanography. He got me into genomics of microbes, specifically of some that lived in the …

… on to work at a groundbreaking company in the early 2000s called Ecopia, which was a very early genome mining company, … mechanistic enzymology to natural product biosynthesis to genomics to directed evolution– but it’s just the– it really … ATP synthase.” On everninomicin biosynthesis: “EvdS6 is a bifunctional decarboxylase from the everninomicin gene …

… approved through the annual  Community Science Program (CSP) call of the U.S. Department of Energy (DOE) Joint Genome … University of Minnesota to establish the Natural Products Genomics Resource Center. To help enable the discovery of …

… the mid-late ’80s. And at that time, you know, it’s before genomics existed. This is before we’re even thinking of … And you know, 25 hours a day we’re at the beach practically. It was just – it was sort of our place to be. And … JGI projects over the years starting with, you know, the CSP that we did and then leading up to today to some …

… and then trying to see if the trees make sense, biologically. So if I can see patterns in that certain clades have … might be similar. And we then researched and made something called a fosmid library, where you chop up the genome and … them and to really answer questions that we have, specifically, with data that are public. DAN UDWARY: So, an episode …