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… Right. Yeah. DAN: Alright, so a subset of proteins are enzymes. Enzymes are proteins that do chemical reactions. And so secondary metabolites come from reactions, of enzymes and sometimes those are referred to as “small …

… And then you search for – re-search for these biosynthetic enzymes that we think must be similar within the fosmid … more into the meta genome mining. We started to build the tools for natural product researchers that easily can … need to be there. Because usually, I get funding for new tools, but really to keep up tools and make them work for a …

… might make this molecule and predicting what kind of enzymes might be involved, and then being able to make those … then they can do one of two things. They can do an ELISA [Enzyme-Linked Immuno-Sorbent Assay] and look for a toxin, or … And why might you use those, or why might you use an enzyme capable of that in an industrial process? Brad: Sure. …

… Environmental Sample Archives, Applying JGI and EMSL Omics Tools introduces the NEON resource, a network of field …

… (2018) Programmed DNA destruction by miniature CRISPR-Cas14 enzymes. Science 362(6416):839-842. Duerkop BA, et al. …

… its potential application in human medicine. And so, we are developing enabling technology, not only to facilitate the … why the stereochemistry was that way. And he told me, it’s enzymes. It’s magic.  BEN:  Yeah, right.  DAN: I thought …

… of always working on natural products but just different tools and how to really access and manipulate these pathways … cool. The vanadium haloperoxidases are some really cool enzymes, and it was fun to see that project take shape. … field, and a lot of people have a lot of different sort of tools and techniques that they bring to it. And we try to …

… little vague to me. What do you mean by putting a bunch of tools in one package? DAN UDWARY: Oh, sure. So if I wanted … use blast or hammer, which are common homology search tools. And I would blast those against the genome that I … ago. Non-ribosomal peptides, remember, are big, complicated enzyme systems that really just exist to pull an amino acid …

… backbone gene synthases, but having a different decoration enzyme actually could give you something that’s quite … I wish we could predict. I wish we could look at these enzymes and predict, and really place it to structure. … you know, how are our crops and people – in particular in developing countries – being affected by parasites.   NANCY: …