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… still work in cell-free environments? (Spoiler: Yes.) Think of cells as tiny factories: within their walls they have … , researchers led by Hal Alper at The University of Texas at Austin and Michael Jewett of Northwestern University describe a two-pronged approach …

The focus of this group, in recent years, has been to bring … The developed strains represent an additional phase of user-accessible project types, in which DNA-based … chromosomally integrated into a taxonomically diverse suite of microbial chassis strains for elevated opportunity for …

Software engineers in the Synthetic Biology Informatics Group develop, deploy, and maintain software that support the JGI’s Synthetic Biology Program .  Representative software includes: gRNA-SeqRET , an organism-agnostic CRISPR …

Our lab is using mass spectrometry based metabolite profiling to provide direct biochemical datasets to improve our understanding of microbial metabolism. Of particular interest is understanding the distributed and …

… ( CRAGE ). CRAGE enables scientists to insert large pieces of DNA (up to 60 kb) in a single step, directly into the genome. “CRAGE is central to our ability to offer host-engineering for our users,” says JGI Director … used CRAGE to engineer domesticated bacterial strains with novel biosynthetic gene clusters (BGCs). BGCs make diverse …

… survival, may now be easier to characterize following a proof-of-concept study in which researchers paired CRISPR and … effectiveness has historically been limited due to the lack of robust tools available for carrying CRISPR into …

… tiny algae. The cold polar oceans give rise to some of the largest food webs on Earth. And at their base are … is displacing these important cold-water communities of algae with warm-adapted ones, a trend that threatens to … beneficial findings, like antibiotics, pharmaceuticals, and novel enzymes that function at low temperature.” said Katrin …

… viruses outnumber the microbes by at least another order of magnitude. For years, scientists at the DOE Joint Genome … in developing and managing public viral genomics resources such as analytical tools and data repositories to … to help uncover the phylogenetic diversity of the human gut microbiome. By bringing their expertise in viral …

Lake Mendota sits right next to the University of Wisconsin, Madison. And Trina McMahon's lab has been sampling the microbes of that lake for over 20 years, to understand how the … giant assembly from Lake Mendota. In this episode: the software evolution that made metagenome assemblies like this …

… human chromosomes 5, 16, and 19. Following the completion of the human genome project in 2003, he developed … 2023. JGI plant gene atlas: an updateable transcriptome resource to improve functional gene descriptions across the … Nature 590: 438-444. Mamidi, S et al. 2020. A genome resource for green millet Setaria viridis enables discovery of …

Genomes from uncultivated bacteria offers clues to ancestral bacteria’s energy sources. More than two billion years ago, cyanobacteria … own food and generate oxygen as a byproduct. The abundance of oxygen shaped the evolution of life on Earth, and led to …

… processing unit (GPU)-based high-performance computing resources, an upcoming hackathon led by the Oak Ridge … Computing Facility (OLCF), NVIDIA, and the Department of Energy (DOE) Joint Genome Institute (JGI), a DOE Office of Science user facility, aims to explore …