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A Redesign for Yeast’s Genome, Chromosome by Chromosome
… To engineer yeast to do more, and understand genomes in general, Jef Boeke, Weimin Zhang (NYU Langone Health) and Leslie Mitchell (Neochromosome) have worked to replace yeast’s native chromosomes with synthetic versions. This project has …
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Unique genomic traits for cold adaptation in Naganishia vishniacii, a polyextremophile yeast isolated from Antarctica
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Emiley Eloe-Fadrosh
… ecology and metagenomics. Her current research focuses on leveraging thousands of metagenomic datasets from host-associated and environmental samples to identify and characterize genomic … more about the program's areas of focus, major initiatives and more.  …
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Whole metagenome sequencing and 16S rRNA gene amplicon analyses reveal the complex microbiome responsible for the success of enhanced in-situ reductive dechlorination (ERD) of a tetrachloroethene-contaminated Superfund site
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For the Tiniest Archaea, A Genomic Switch of Friend or Foe
… Meta-omics datasets show that CRISPR-Cas systems determine mutualism or … are abundant and yet exceptionally small, with mini genomes to match. As a result, they cannot process all of the chemicals they need to survive. To fill in their nutrient gaps, they must latch onto a …
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New and Improved: Eucalyptus Reference is Now Accessible
… An improved genome assembly to support targeted tree breeding for … eucalyptus in the July edition of the journal G3 Genes | Genomes | Genetics , with significant advances compared to the 2014 Eucalyptus grandis reference … WIP proposal ID: 508017, Myburg, Wegrzyn, Borevitz) conducted by the US Department of Energy Joint Genome …
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JGI Scientists Pen Genome Watch Articles
… JGI researchers made their debut writing for the Nature Reviews Microbiology column last year — and there’s more to … move toward characterizing the human microbiome  by its genomes and metagenome , rather than just by 16S ribosomal RNA gene censuses.  Emiley Eloe-Fadrosh ,  …
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Learning to Look
… Machine learning approach significantly expands inovirus diversity. To answer the question, “Where’s Waldo?” … a similar type of search in microbial and metagenomic databases. In this case, the machine “learned” to identify a … are filamentous viruses with small, single-stranded DNA genomes and a unique chronic infection cycle. “We’re not …
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Designer DNA: JGI Helps Users Blaze New Biosynthetic Pathways
… what genes do, how they work, and applying them to environmental and energy challenges. But not all scientists … more than 10 papers, including two Nature Plants publications, in five years, have come out of the … is famous for its work sequencing human and environmental genomes. But we now have these DNA synthesis capabilities …
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The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction
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Triggering Morel Fruiting
… A collaborative team led by Hao Tan from the Sichuan Academy of … external source.  The work is part of the JGI’s 1000 Fungal Genomes Project, which aims to provide genomic information … to an increasingly detailed portrait of molecular features triggering morel fruiting. They include: A diverse …
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Computationally Classifying Fungal Lifestyles
… Machine learning methods were applied on sequenced fungal genomes to classify gene families. The Science As a proof of concept, researchers developed an algorithm that “taught” a computer how to … Vector Machine (SVM)-based prediction of lifestyle based on 6 gene clusters showed a >95 % accuracy in correctly …
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