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Gut Fungi: Unexpected Source of Novel Chemicals
… off early from aerobic fungi, which can breathe oxygen — just like we do. Oxygen is a rich source of energy, and because anaerobic fungi can’t harness it, scientists long held … proposal. The next step for the team was to try to identify what natural products the fungi were making. So, Trent …
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How Maize Makes An Antibiotic Cocktail
… a family of compounds that protects it against infections — using surprisingly few enzymes. The Science Maize ( Zea mays … called zealexins. Even though scientists have identified at least 15 zealexins, they suspect there are even more to find. Zealexins are produced …
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The Expanding Universe of Methane Metabolisms in Archaea
… insights into an ancient metabolism. Methane is a greenhouse gas 20 times more potent than carbon dioxide. Billions … (DOE) Joint Genome Institute (JGI), a DOE Office of Science User Facility, for publicly available metagenome data … and short-chain alkane oxidation metabolisms. They also identified a set of 38 marker genes that serve as a core set of …
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Celebrating a Decade of Science through the JGI-UC Merced Genomics Internship Program
… the summer of 2014 has grown to a total of 75 with the inclusion of the 2023 cohort. Each of them has brought … efforts to contribute towards a diverse workforce and scientific community (working with the JGI) as well as our … have a number of initiatives across several different campuses with this being our largest and most successful one. …
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An Age of CRAGE: Advances in Rapidly Engineering Non-model Bacteria
… is central to our ability to offer host-engineering for our users,” says JGI Director Nigel Mouncey. Using CRAGE, JGI has established a portfolio of microbial hosts that users can select to be engineered. “Piloting access to this …
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Learning to Look
… Machine learning approach significantly expands inovirus diversity. To answer the question, “Where’s Waldo?” … (DOE) Joint Genome Institute (JGI), a DOE Office of Science User Facility, developed an algorithm that a computer could … databases. In this case, the machine “learned” to identify a certain type of bacterial viruses or phages called …
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Ian Blaby
… the Joint Genome Institute, where he leads three groups focused on HTP DNA design and assembly, strain engineering and … a group lead at Brookhaven National Laboratory where he focused on functional genomics of phototrophs. Through this and … systems. PloS one. 15: 11. 2020 Blaby & Cheng, Building a custom high-throughput platform at the Joint Genome Institute …
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JGI@25 RECAP: 2022 Annual Meeting features historical perspectives on JGI’s 25 years
… all that it has contributed, and what they’re excited about in JGI’s future. Find recordings and recaps of these … and Environmental Research “There are two kinds of scientific revolutions,” Ari Patrinos opened with this quote from … to be junk DNA, so there was quite a bit of resistance to use resources to sequence it,” Patrinos said. After many …
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Crysten Blaby-Haas
… Molecular Foundry, a nanoscale research and knowledge-based user facility at Berkeley Lab. She is spearheading the development of a joint user capability between the JGI and Molecular Foundry for … of Florida, working with Valérie de Crécy-Lagard on using comparative genomics to predict gene function in …
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Yasuo Yoshikuni
… Biology Pathway Engineering group. His research focus includes engineering of non-model yeasts for production … microbe-microbe and plant-microbe interactions in various environments to improve crop yield, and developing a … startup, Bio Architecture Lab, Inc. (BAL), where he used systems and synthetic biology to discover novel …
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DAS Tool for Genome Reconstruction from Metagenomes
… The work aligns with the ETOP mission of providing JGI users with the most current technology and expertise in order to address pressing energy and environmental scientific challenges. In Nature Microbiology , a team led by … and soil from the Angelo Coast Range Reserve in California. Using DAS Tool on data from soil samples, researchers were …
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A Pinch of Salt Activates Silent Gene Clusters in Streptomyces
… This single environmental trigger highlights efficiency for users requiring multiple omics methods to examine microbial … chemical production. The Science Soil bacteria in the genus Streptomyces are nature's chemical factories. They hold … can use to design more efficient microbial factories. Identifying specific genes, regulatory elements and metabolic …
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