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A Natural Mechanism Can Turbocharge Viral Evolution
… ago, a team discovered a group of viruses that had in their genomes a surprising tool: a “diversity generating … this analysis, a 20-fold increase over what was previously known, throws open the doors to characterizing how DGRs work … and through a Challenge Grant from the California NanoSystems Institute at the University of California Santa …
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The Expanding Universe of Methane Metabolisms in Archaea
Metagenome-assembled archaeal genomes provide new insights into an ancient metabolism. … lineages, and the other five only distantly related to known methanogens. With the help of this information, the … sequencing and computational analysis that enable systems-based scientific approaches to these challenges.  …
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Better Genome Editing for Bioenergy
… lipid production. These insights into  Y. lipolytica biology and lipid metabolism furthers the U.S. Department of … They identified four genes, including one with no prior known function. The project’s success demonstrates how to …
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Tracking the Origins of Methane-Producing Microbes
… pathways require the gene cluster for methane production known as Mcr. Until recently, the Mcr gene cluster was found … separately. From these samples, 111 metagenome-assembled genomes (MAGs) were recovered, most of them archaea. The … sequencing and computational analysis that enable systems-based scientific approaches to these challenges.  …
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Boosting Small Molecule Production in Super “Soup”
… would be transformative at industrial scales. “Cell-free systems have been really powerful at finding ways to … metabolic performance, Alper noted. “This was really an unknown exercise,” he added. “It wasn’t a proven premise that … you can rewire one and get the other’ – but, that was not a known fact in the field whatsoever.” Focusing on Carbon Flux …
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Applying Viral Genomics Expertise to Understanding the Human Virome
… available to the research community. Kyrpides’ project, “ Advanced analytics for uncovering virus dynamics and … workflows that allow researchers to easily analyze viral genomes. This includes (i) classifying viruses into groups … sequencing and computational analysis that enable systems-based scientific approaches to these challenges.  …
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JGI Early Career Researchers Featured in mSystems Special Issue
… sequences in soil for the first time. A second approach known as DNA stable isotope probing (DNA SIP) relies on … processes. A third approach steps away from reconstructing genomes directly from the environment and focuses on … last few years, mapping the planet’s viral diversity has advanced drastically, aided by genome assembly from …
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Ancient Algae Reveal Secrets of Plant Evolution
… genetic foundations that helped plants conquer land over 600 million years ago. The Science By studying the genes of … Laboratory (Berkeley Lab), scientists sequenced the genomes of four  Zygnematophyceae algae, which were isolated … a better understanding of plant evolution and could lead to advancements in improving plant resilience and productivity. …
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SPRUCE-ing Up Science
… brings a bioinformatics expertise, a combination of biology and computer science, to reveal clues about how … “This makes it one of the most efficient carbon-sucking ecosystems on the planet,” Lawrence said. For Lawrence, this …
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Cultivating Symbiotic Antarctic Microbes
The Impact The Antarctic lakes are a “treasure trove” of unknown microbes that play critical roles in environmental … consequences of microbe-microbe interactions. Using metagenomes recovered directly from environmental samples and … about how microbes have adapted to thrive in polar ecosystems. The work by Cavicchioli’s team sheds light on the …
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JGI@25: Following Fungi that Pry Apart Plant Polymers
… an assistant professor at the University of Delaware — is  building on this work to explore an enzymatic ‘toolbox’ of … transporters, pathways — into microbes that we do know, to advance our biotech goals.” …
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JGI User Executive Committee Expands
… how these changes affect the dynamics and functioning of ecosystems. She leads a recently approved CSP New … decomposition. She’s also participated in the 1000 Fungal Genomes Project and has an interest in cross-disciplinary …
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