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… are the RiPPs, which stands for “Ribosomally synthesized and Post-translationally modified Peptides.” You’ll have … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… readiness to begin work, checking such factors as genome size, polymorphism level, sample quality and availability, … For sequencing projects, once work is under way, raw sequence data is released to NCBI’s Sequence Read Archive on … at large. In most cases where the JGI provides more customized analysis, the JGI also participates in publication of …

… To meet these needs, the JGI deploys state-of-the-art sequencers and platforms dedicated to synthesis, single-cell … same time, the team is expanding current capabilities in strain engineering and functional assays and supporting new …

… at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways … studied and in academia and industry can make many dozens of them. Some are going to be involved in antibiotic …

… Apple Podcasts or wherever you’re getting this and tell me why you’re listening. DAN: But, now, here’s Natural Prodcast … one more interview to do at SIMB. And sitting in the crazy hotel chair now is Roger Linington. Roger is a professor … And that’s been followed by developments in pulse sequences and improvements in the ways in which you acquire …

… and bacteria, basically all living things. When your crazy Aunt is posting on Facebook about cinnamon or turmeric … stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain … more about some of the background and sort of the reasons why we want to do this. And also to provide a little more …

… chemistry, and he has a project with the JGI to synthesize the genes for and explore the chemistry of quorum sensing … of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. …

… Our research is focused on the discovery and characterization of novel bacterial, archaeal and eukaryotic microbes and viruses in environmental sequence data. We use multi-omics (metagenomics, … evolution Our research focuses on discovering and characterizing giant viruses, which possess genomes and particle sizes …

… happy today to be handing over our interview with Dr Elizabeth (or Betsy) Parkinson from Purdue University. She’s in … The genes are pretty much 100% identical. We don't know why one is expressed over the other. As far as whether we're … usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain …

… still almost certainly unusual things that we don’t recognize, because the only way to find things is by comparison. … DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have …

… in the analysis and publication of the claimed genome sequences. This opportunity, provided by the Joint Genome … builds upon thousands of microbial genomes that have been sequenced by the JGI though not formally analyzed or published.  The purpose of the program is to: Build …