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… DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have … molecules and their discoveries over a stretch from 1940 to 2000. As you can see, from the 1940s, into the 50s …

… culture-disconnected. Like we’ll take some soil samples and sequence all the bugs out of that or whatever. And so I was … methicillin-resistant Staphylococcus aureus . Can you share why finding treatments for these microbes is so important? … of infectious or inflammatory disease and these same species are being used not just by one generation but by …

… metabolites all refer to the chemicals that make species unique and different from one another. They are …

… And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … that if you looked at the grant applications for the last 40 years for studying biosynthetic pathways, all of them …

… at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways … the United States in … I forget the number, but it’s over 42, 43 states, but we’re also in many countries, including …

… Phytozome (citation: https://doi.org/10.1093/nar/gkr944 ) The following tools are available for functional … I request a culture/slant/DNA of an organism that has been sequenced at the JGI? …

… with an active JGI User Agreement older than January 2024 will be required to execute a 2024 version .  The recent updates were approved by the DOE to … must be in place.  This is in addition to an active 2024 User Agreement or JGI BDLUA. MATERIAL TRANSFER AGREEMENT …

… comprising the largest public collection of plasmid sequences identified from genomes, SAGs, MAGs, metagenomes …

… tool BOOST , which provides a suite of tools to automate sequence design for assembly by Gibson, Yeast recombination …

… (see Auspice Statement below) for the generation of sequence or metabolomic data, DNA synthesized, and any other …

… of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. … nice summer day in Seattle I think this was like 2013 or 2014. And antiSMASH — I know you’ve interviewed Marnix [Medema] …