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… research, and also to talk to the wider natural products community about what they need to advance their science, and … stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain … right. So I did a PhD in microbiology at MIT, and I studied microbial ecology. I studied Vibrio species in the ocean, so …

… determine if these fungi act as friends or foes. The Impact Microbial communities comprised of fungi and bacteria can … Communications paper . The work was partly enabled by a JGI Community Science Program (CSP) proposal led by INRAE’s … from natural Arabidopsis populations around Europe. The JGI sequenced and annotated 41 fungal isolates from the …

… of their synthases so that we can start to use the DNA sequence to predict or just understand better the language of microbial cell-cell communication. And he told us about his … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. …

… then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … and Bill Fenical. And we connected to JGI through the Community Sequencing Program, and they worked with us to … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against …

… would say that when I first started out the natural product community was almost 100% bacterial. Only people working in … out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk …

… interactions with their environments and with each other, from defending against predators to aiding in symbiotic … computational analyses of BGC size and complexity, BGC sequence composition, metabolic similarity & compatibility, … and debate about the data. It is also a place where the community can upload new data for use by scientists and the …

And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … of thought with that. So some people are interested in cave microbial– people are interested in the more extreme …

… is a bacterial sacred metabolite, and ergot alkaloids come from fungi, and Taxol from plants. Plants, fungi, bacteria, … DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have …

Below is a brief description of the process needed to prepare and … QC Protocol DNA Extraction 101 : tips, kits, and protocols (from PacBio) Guidance for sample collection and storage … pipelines.  You will receive automated emails as raw sequence data becomes available, and as analysis is …

Apple Podcasts or wherever you’re getting this and tell me why you’re listening. DAN: But, now, here’s Natural Prodcast … to try and create an open source database of all known microbial natural products. So if you think about natural … And that’s been followed by developments in pulse sequences and improvements in the ways in which you acquire …

Research in the Eloe-Fadrosh group focuses on using … approaches to identify and characterize genomic information from uncultivated microbes and viruses. We develop … of metagenomes for signatures of viruses and novel microbial lineages, and reconstruct metabolic properties …

The Facilities Integrating Collaborations for User Science … FICUS call with EMSL begin with a Letter of Intent (LOI) from a researcher, briefly describing the project … samples of the spatial, temporal, taxonomic (environmental, microbial, plants, invertebrate, and vertebrate), and …